22. Clinical conditions of the cervical and thoracic spine Flashcards

1
Q

what is cervical spondylosis?

A

Cervical spondylosis is a chronic degenerative osteoarthritis affecting the
intervertebral joints in the cervical spine

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2
Q

what is the primary pathology of cervical spondylosis?

A

The primary pathology is usually age-related disc degeneration, which is followed by marginal osteophytosis (osteophyte formation adjacent to the end plates of the vertebral bodies) and facet joint osteoarthritis

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3
Q

why might cervical spondylosis lead to radiculopathy?

A

The resultant narrowing of the intervertebral foramina can put pressure on the spinal nerves leading to radiculopathy

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4
Q

What are the symptoms of radiculopathy?

A

Symptoms of radiculopathy include dermatomal sensory symptoms (e.g. paraesthesia, pain), and myotomal motor
weakness.

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5
Q

Why might cervical spondylosis lead to myelopathy?

A

If the degenerative process leads to narrowing of the spinal canal, this may instead put pressure on the spinal cord leading to myelopathy. This is a less common outcome than radiculopathy, and may manifest as global muscle weakness, gait dysfunction, loss of balance and/or loss of bowel and bladder control. These symptoms arise due to compression and dysfunction of the ascending and descending tracts within the spinal cord

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6
Q

What is the difference between radiculopathy and myelopathy?

A

Radiculopathy
• compression of nerve roots
• Osteophyte in the Foramen -

Myelopathy
• compression of spinal cord
• Osteophyte in the Vertebral Canal
• thickening ligamentum flavum

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7
Q

What is the triad for cervical spondylosis?

A
  • Loss of Disc Height
  • Osteophytes
  • Facet Joint Osteoarthritis
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8
Q

What is the Jefferson’s fracture?

A

Jefferson’s fracture is a fracture of the anterior and posterior arches of the atlas
vertebra (C1). The fracture causes the C1 vertebra to burst open like a broken Polo® mint.

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9
Q

What can cause jefferson’s fracture?

A

The mechanism of injury is axial loading e.g. diving into shallow water,
impacting the head against the roof of a vehicle, or falling from playground
equipment. Patients may present to the Emergency Department supporting their
head with their hands.

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10
Q

Are there any neurological signs associated with Jefferson’s fracture?

A

Fortunately, the ‘bursting open’ of the bone fragments reduces the likelihood of impingement on the spinal cord. This fracture therefore typically causes pain but
no neurological signs.

Occasionally, however, there may be damage to the arteries at the base of the skull leading to secondary neurological sequelae e.g. ataxia, stroke, or Horner’s
syndrome.

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11
Q

What is horner’s syndrome?

A

Horner’s syndrome is damage to the sympathetic trunk leading to miosis
(decreased pupil size), partial ptosis (drooping eyelid), anhidrosis (decreased
sweating on the affected side of the face) and enophthalmos (sunken appearance
of the eyeball)

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12
Q

What is the Hangman’s fracture?

A

In a Hangman’s fracture, the axis vertebra (C2) is fractured through the pars
interarticularis (the region between the superior and inferior articular processes).
– Unstable fracture
– Forward displacement of C1 and C2 on C3

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13
Q

What can cause hangman’s fracture?

A

The mechanism of injury is usually
forcible hyperextension of the head on
the neck; historically by ‘hanging’ and
more recently in road traffic collisions.

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14
Q

Does hangman’s fractres damage the spinal cord?

A
This fracture is unstable and requires
treatment. As with Jefferson’s fractures
of the C1 vertebra, the fracture
configuration tends to expand the spinal
canal, thereby reducing the risk of an
associated spinal cord injury
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15
Q

what can cause fractures of the odontoid process (peg fractures)?

A

• either flexion or extension injuries.
• The most commonly seen mechanism is an elderly patient with osteoporosis falling forwards and impacting their forehead on the pavement.
• This hyperextension injury of the cervical spine can result in a fracture of the
odontoid peg.
• Alternatively, sometimes these fractures are caused by a blow to the back of
the head resulting in a hyperflexion injury e.g. falling against a wall when
balance is compromised (such as when intoxicated)

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16
Q

How can fractures of the odontoid process be seen?

A

This fracture can be detected on an ‘open mouth’ AP X-ray or a CT of the
cervical spine (performed either as part of a ‘trauma series’ or during a CT scan
of the head).

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17
Q

What is whiplash injury and why are we very prone to it?

A

The head accounts for 7-10% of the total body weight. It is balanced on the cervical spine, which has high mobility and therefore low stability (as mobility and stability of joints are inversely related). The cervical spine is therefore very prone to whiplash
injury, which is a forceful hyperextension-hyperflexion injury of the cervical spine.

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18
Q

What is the classical mechanism of the whiplash injury?

A

The classical mechanism is the patient’s car being struck from the rear leading to an
acceleration-deceleration injury as follows:
 At the time of impact, the vehicle suddenly accelerates forward. About 100
ms later, the patient’s trunk and shoulders follow, induced by a similar acceleration of the car seat.
 The patient’s head, with no force acting on it, remains static in space. The result is forced extension of the neck, as the shoulders travel anteriorly under the head. With this extension, the inertia of the head is overcome, and the head then accelerates forward.
 The neck then acts as a lever to increase forward acceleration of the head, forcing the neck into flexion.

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19
Q

After whiplash occurs, what secondary injuries may a patient complain of

A
  • Arm pain and paraesthia (spinal nerve damage)
  • Shoulder injuries (if holding the steering wheel)
  • Lower back pain
  • Chronic myofascial pain syndrome: secondary tissue response to disc or facet injury, chronic pain
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20
Q

How can whiplash result in the injury to the cervical cord

A

Sometimes whiplash can result in injury to the cervical cord, despite there being no accompanying bony fracture. The cervical spine is highly mobile and the
ligaments and capsule of the joints are weak and loose. Hence, there can be significant movement of the vertebrae (e.g. subluxation or dislocation) at the time of impact, with return to the normal anatomical position afterwards. Soft tissue swelling may be the only visible feature on imaging.

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21
Q

What is a protective factor against spinal cord injuries in the cervical spine

A

A protective factor against spinal cord injury is that the vertebral foramen is large relative to the diameter of the cord. The normal diameter of the cervical spinal
canal is 17-18 mm. The average diameter of the spinal cord in the cervical region is 10mm.

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22
Q

In which age group does cervical inter vertebral disc prolapse mainly occur?

A

Cervical disc prolapse with associated compression of nerve roots or spinal cord most commonly develops in the 30 to 50 year-old age group.

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23
Q

describe the mechanism of disc herniation

A

• The mechanism of disc herniation is similar to that seen in the lumbar spine in that a tear develops in the annulus fibrosus of the disc, and the nucleus pulposus protrudes from the disc, with impingement onto an adjacent nerve root or the spinal cord
• [Note that in the cervical region, it is the spinal cord, not the cauda equina that is compressed].
• Sometimes sequestration occurs in which an extruded segment of nucleus pulposus separates from the main body of the disc and enters the spinal canal where it is ultimately resorbed over a period of weeks, with resolution of symptoms.
• Cervical intervertebral disc prolapse may be spontaneous in origin or may be related
to trauma and neck injury.

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24
Q

Why might even a small disc herniation cause significant pain?

A

The discs in the cervical spine are not very large. However, there is also little space available for the exiting nerves (unlike in the lumbar spine) so even a small cervical disc herniation may impinge on the nerve and cause significant pain.

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25
Q

What are the symptoms of cervical intervertebral disc prolapse

A

Symptoms are dependent on the site of the prolapse. Paracentral prolapse may impinge on a spinal nerve leading to radiculopathy (compression of a spinal
nerve) whereas a canal-filling prolapse may lead to acute spinal cord compression.

26
Q

In cervical intervertebral disc prolapse, which nerve roots will be compressed?

A

In the cervical spine, it is the exiting nerve root that will be compressed.

27
Q

What will a patient complain of in a left-sided C5/6 prolapse?

A
  • the cervical nerves exit above their respective vertebrae, so the exiting nerve root at C5/6 is C6.
  • the cervical spinal nerves travel much more horizontally from the spinal cord to the intervertebral foramen than lumbar nerves do, so there is no traversing nerve root, just an exiting nerve root.
  • The nerve being compressed is therefore C6.
  • The patient may complain of paraesthesia in the left C6 dermatome (radial border of left forearm, thumb and index finger) and have weakness in the left C6 myotome (weakness of left elbow flexion, supination and wrist extension).
  • The patient will experience pain in their neck that will radiate down the left arm (often felt over the biceps) into the skin supplied by the C6 dermatome.
28
Q

What is cervical myelopathy?

A

Cervical myelopathy is spinal cord dysfunction due to compression of the cord.
It is caused by narrowing of the spinal (vertebral) canal.

29
Q

What are the damaging effects of a whiplash injury?

A
  • tearing of cervical muscles and ligaments

- secondary oedema, haemorrhage and inflammation may occur

30
Q

How do the muscles respond to injury in whiplash and what is the consequence of this?

A

The muscles respond to injury by contraction (spasm), with surrounding muscles being recruited in an attempt to splint the injured muscle. This spasm causes pain and stiffness

31
Q

What is compressed in a cervical paracentral disc prolapse and a canal-filling prolapse?

A

Paracentral: exiting nerve root that will be compressed (no traversing spinal nerve)

Canal-filling: acute spinal cord compression

32
Q

What are causes of cervical myelopathy?

A
  • degenerative stenosis of the spinal canal caused by cervical spondylosis (degenerative osteoarthritis)
  • congenital stenosis of the spinal canal
  • cervical disc hernication
  • spondylolisthesis
  • trauma
  • tumour
  • rheumatoid arthritis affecting the cervical spine
33
Q

What degenerative changes lead to cervical sponylylotic myelopathy(myelopathy secondary to cervical spondylosis)?

A
  • ligamentum flavum hypertrophy or buckling
  • facet joint hypertrophy
  • disc protrusion
  • osteophyte formation

One or all of these changes contribute to an overall reduction in canal diameter which may result in cord compression.

34
Q

When do symptoms of congenital stenosis of the spinal canal appear?

A

asymptomatic until adulthood when age-related secondary degeneration starts to occur

35
Q

What is the normal diameter of the spinal canal and cord and below what diameter do myelopathic symptoms appear?

A

Spinal canal is 17-18 mm, spinal cord in the cervical region is 10mm.
When the diameter of the spinal canal falls below
12-14mm, myelopathic symptoms may be experienced

36
Q

What is spondylolisthesis?

A

Anterior slippage of a vertebral body on the vertebra below

37
Q

Why are symptoms of both the upper and lower limbs present in cervical myelopathy?

A

due to damage to the long tracts of the spinal cord

38
Q

How does cervical myelopathy manifest in older patients?

A

Rapid deterioration of gait and hand function

39
Q

What are the symptoms of cervical myelopathy?

A

The classical presentation is loss of balance with poor coordination, decreased dexterity, weakness, numbness and in severe cases paralysis. Pain is a symptom in many patients but it is important to remember that it may be absent; the absence of pain often leads to a delay in diagnosis

40
Q

What are the common presentations of upper cervical lesions?

A

Loss of manual dexterity with difficulties in writing and nonspecific alteration in arm weakness and sensation. Patients may demonstrate dysdiadochokinesia

41
Q

What is dysdiadochokinesia?

A

impaired ability to perform rapid alternating movements

42
Q

What are the common presentations of lower cervical lesions?

A

Tend to lead to spasticity [increased muscle tone, sometimes with clonus] and loss of proprioception in the legs. Patients commonly say that their legs ‘feel heavy’ and experience reduced exercise tolerance. They typically have gait disturbance and may suffer multiple falls

43
Q

What is the effect of a damaged long tract (connect spinal cord to brain) and what tests can be used to detect it?

A

Normally the signals in the long tracts dampen the spinal reflexes, so a person does not overreact to stimuli. When the long tracts become damaged, however, these protective capabilities are less effective, and the Patient may demonstrate an exaggerated response to stimulation, as seen in a positive Hoffman’s or Babinski sign

44
Q

What is the Hoffman’s test?

A

Doctor holds the patient’s middle finger at the middle phalanx and flicks the finger nail.

  • If there is no movement in the index finger or thumb after this motion, the patient has a negative Hoffman’s sign (normal).
  • If the index finger and thumb move, the patient has a positive Hoffman’s sign (abnormal)
45
Q

What is the Babinski’s test?

A

Lateral side of the sole of the foot is stroked with a blunt instrument from the heel towards the toes.

  • Normally in children over the age of approximately 2-3 years and adults, the response is flexor in that the toes flex downwards towards the sole (plantarflex).
  • In a positive (abnormal) Babinski sign, the hallux dorsiflexes and the toes fan out. This suggests damage to the long tracts of the spinal cord.
46
Q

What is L’Hermitte’s phenomenon?

A

Sensation of intermittent electric shocks in the limbs, exacerbated by neck flexion. It is classically associated with cervical myelopathy

47
Q

What are the symptoms of severe cervical myelopathy?

A

if surgical decompression is not performed the symptoms may progress to sphincter dysfunction and quadriplegia (paralysis of all four limbs)

48
Q

If a patient develops myelopathy of the cervical spine at the level of C5 (with a C4 neural level - the lowest intact level of sensation and function), what are the likely symptoms?

A

Pain: Neck pain

Motor weakness: Weakness of shoulder abduction and external (lateral) rotation (C5) and weakness of all myotomes distally (see image below), including the trunk and the lower limbs

Sensory: Paraesthesia from the shoulder distally, trunk and lower limbs.

49
Q

What are the 2 most common causes of thoracic cord compression?

A
  • vertebral fractures (with bony fragments in the spinal canal)
  • tumours in the spinal canal
50
Q

What are the most common cancers that spread to bone?

A

breast, lung, thyroid, kidney and prostate

51
Q

In which part of the spine do the neural segments do not line up with their respective vertebral segments and why?

A

In the lower thoracic and lumber spine

- because the spinal cord is much shorter than the vertebral column

52
Q

What is important to consider in a lower thoracic spinal cord compression?

A

Spinal cord shorter than the vertebral column so a lower spinal compression usually affects spinal nerves of greater value
e.g. T10 vertebra is aligned with the T11-12 segments of the spinal cord

53
Q

If there was a tumour at T10, how would it present?

A

Symptoms of spinal cord compression from this metastasis would therefore include pain at the site of the lesion (thoracic spine), spastic paralysis of all of
the muscles in the legs, paraesthesia in the dermatomes distal to the site of cord compression (i.e. from a few centimetres below the umbilicus distally), and loss of sphincter control.

54
Q

If there was a tumour at T5, how would it present?

A

In addition to the symptoms above, there would be weakness of the intercostal muscles from the 5th intercostal space distally, leading to reduced chest expansion on inspiration and the patients predominantly relying on diaphragmatic breathing (phrenic nerve C3,4,5). The distribution of the paraesthesia would be from just below the nipples distally. [The patient would also still exhibit weakness of all the muscles in their legs and loss of sphincter control.]

55
Q

How can pathogens reach the bones and tissues of the spine?

A
  • Haematogenous (most common route and typically occurs via the arterial supply to the vertebral bodies,
    but can also occur through retrograde (backwards) venous flow)
  • Direct inoculation during invasive spinal procedures (e.g. lumbar puncture, epidural or spinal anaesthesia)
  • Spread from adjacent soft tissue infection
56
Q

What is infection of the intervertebral discs called?

A

Spondylodiscitis or just discitis

57
Q

In which patients does spondylodiscitis occur?

A

Immunocompromised patients e.g. those with diabetes, HIV and patients on steroids

58
Q

How does infection spread to a intervertebral disc in adults?

A

In adults, the intervertebral disc is avascular and it is thought that organisms are therefore initially deposited in the vertebral body, leading to bony ischaemia and infarction. Necrosis of the bone then allows direct spread of organisms into the adjacent disc space, epidural space and adjacent vertebral bodies.

59
Q

How does spread of infection into the spinal canal lead to neurological damage?

A
  • Septic thrombosis leading to ischaemia
  • Compression of neural elements by abscess / inflammatory tissue
  • Direct invasion of neural elements by inflammatory tissue
  • Mechanical collapse of bone leading to instability, particularly in chronic infections
60
Q

What are the common organisms infect the spinal canal?

A
  • Staphylococcus aureus (50%)
  • and Gram negative bacilli such as Escherichia coli (up to 30%)
  • Following invasive spinal procedures, coagulase negative Staphylococci (e.g. Staph epidermidis) become more frequent (up to 30%)
61
Q

What organisms have been found to infect the spinal canal in IV drug users?

A

More unusual organisms (e.g. Pseudomonas, Candida)