Physio Hormones Flashcards

1
Q

Salivary glands receive input from

A

PNS and SNS

BOTH enhance secretions (unique)

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2
Q

SNS: Celiac ganglia contribute to gut all the way up to distal colon, then at Distal,

A

the Sup/Inf Mesenteric ganglion take over

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3
Q

Where is CCK made

A

I cells of duodenum and jejunum

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4
Q

Where is Gastrin made

A

G cells of stomach

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5
Q

Where is Secretin made

A

S cells of duodenum

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6
Q

Where is GIP made

A

Duodenum and jejunum

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7
Q

Gastrin

A

Release of H in stomach, Gastric mucosa growth

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8
Q

CCK

A

Acts at various locations (Pancreas, gallbladder)

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9
Q

GIP

A

Increase insulin secretion

Slow stomach stuff: decrease emptying and H+ secretion

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10
Q

Secretin

A

Increase BICARB secretion

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11
Q

GIP released in small intestine as result of

A

Presence of breakdown of food stuff

(+) Insulin release
(-) gastric H secretion and emptying

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12
Q

Why can we respond so quickly to oral glucose?

A

Thx to GIP: Glucose dependent Insulinotropic Peptide

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13
Q

GI Paracrines (2)

A

Somatostatin

Histamine

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14
Q

Main GI Hormones (4)

A

Gastrin
CCK
Secretin
GIP

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15
Q

Main GI Paracrines (2)

A

Somatostatin

Histamine

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16
Q

Main GI Neurocrines (5)

A
Ach
NE
NO
VIP
GRP
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17
Q

BER (Basal electrical rhythm) originates in

A

Interstitial Cells of Cajal
“pacemaker cells”
(in Myenteric plexus)

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18
Q

What factor of BER is unchanged by neurocrines?

A

Frequency

Unchanged. Only depends on location in GI tract

19
Q

Migrating Motor Complex is regulated by

A

Motilin

20
Q

MMC function

A

“housekeeping”
remove un-digested food- propel it forward

every 90 min

21
Q

MMC

A

Interdigestive

starts 2 hrs after eating

22
Q

Cephalic phase

A

Nervous component
Hormonal component

Prep the whole GI tract for food

23
Q

Cephalic phase: PNS

A

PNS increases secretion of saliva, gastric acid, gastrin, and pancreatic enzymes

24
Q

Major components of Saliva

A
Mucus
A-amylase
Lingual lipase
Alkaline solution 
IgA
25
Q

Saliva is _____ to plasma

A

Hypotonic

26
Q

What is higher in saliva than plasma?

A

K and Bicarb

27
Q

A high saliva secretion rates,

A

Saliva starts to look more and more like plasma (except for Bicarb)

28
Q

As saliva secretion increases

A

Bicarb increases (prevent reflux)

29
Q

Why is saliva hypotonic?

A

More NaCl is removed than Bicarb and K put back in

removing more electrolytes than returning

30
Q

PNS stimulation of saliva

A

ACh and VIP

31
Q

What drug interferes with ACh on Muscarinic receptor

A

Atropine

32
Q

What inhibits saliva production

A

Fear
Dehydration
Sleep

33
Q

What stimulates saliva production

A

Conditioning
Food
Nausea
Smell

34
Q

Organization of stomach

A

Longitudinal
Circular
Oblique

35
Q

Vagovagal reflex

A

Release of VIP, relaxation of LES and Orad stomach (allowing passage of food from Esophagus to Stomach)

36
Q

What is the Alkaline tide

A

Bicarb being secreted into the blood as a result of the HCl being secreted into gut lumen

Blood becomes more basic

37
Q

What 3 substances have a Synergistic effect on H+ release into lumen?

A

ACh
Gastrin
Histamine

38
Q

H+ release, 3 important contributing factors

A

ACh –> M3 receptor

Gastrin –> CCKB receptor

Histamine –> H2 receptor

39
Q

How does Cimetidine work?

Medicine

A

Blocks Histamine from binding to H2 receptor

40
Q

Histamine (a paracrine)

A

leads to increased H+ secretion

41
Q

Proton pump creating H+

A

Ach, Gastrin, and Histamine acting on PARIETAL CELL

42
Q

What 2 substance inhibit H+ secretion from PARIETAL CELL

A

Somatostatin

Prostaglandins

43
Q

Cimetidine

Ramitidine

A

H2 blocker med

44
Q

PPI (H-K ATPase blocker)

A

Omeprazole