Immunodeficiency

Question 1

What and how do primary immunodeficiencies effect?

Answer 1

Immune cell development and function through gene mutations

Question 2

What are the consequences of primary immunodeficiencies?

Answer 2

Deficient immune response leading to recurrent infections

Question 3

What does T cell deficiency pre-dispose yo to?

Answer 3

Viral/fungal infections

Question 4

How does understanding immunodeficiencies develop scientific understanding?

Answer 4

Of specific roles of cells

Question 5

SCID

Answer 5

Severe combined immunodeficiency

Question 6

What does SCID effect?

Answer 6

T cell development - no T cells, no antibodies, no memory

Question 7

What mutations cause SCID?

Answer 7

In genes for cytokine signalling molecules meaning there are a lack of cells relying on this signal

Question 8

Treatment for SCID?

Answer 8

Bone marrow transplant

Question 9

CVID

What does it effect?

Answer 9

Common variable immunodeficiency

IgA production

Question 10

What causes hyper IgE deficiency syndrome?

Answer 10

Mutation in TF regulating Th17 differentiation = Th17 deficiency

Question 11

Oral manifestations of hyper IgE deficiency syndrome?

Answer 11

Supernumerary, ameolgenesis imperfecta

Question 12

Cause of XLA?

Answer 12

Failure of B cell receptor signalling leading to a lack of antibodies

Question 13

What causes acquire immunodeficiency?

Answer 13

Immunosensense (age, nutrition) drugs smoking