Obstetrics and Gynaecology Flashcards

1
Q

What is candidiasis?

A

A fungal infection due to any type of Candida (type of yeast)
Also known as thrush

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2
Q

What is the aetiology of candidiasis?

A

Candida normally lives on the skin and inside the body, in places such as the mouth, throat, gut, and vagina, without causing any problems. Candida can cause infections if it grows out of control or if it enters deep into the body (bloodstream or internal organs)

Although mucosal disease is common, invasive disease is not, and the primary reason is that Candida species in general are unable to enter intact epithelium

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3
Q

What are the risk factors for candidiasis infections?

A

Immunosuppressive agents e.g. systemic corticoid steroid use
Current or recent past use of brand spectrum antibiotics
Malabsorption/ malnutrition
HIV infection
Poor oral hygiene (oral candidiasis)
Endocrine disturbances (DM, pregnancy, hypoadrenalism) - reduce effectiveness of immune system

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4
Q

What are the presenting symptoms of candidiasis infections?

A
Oral: 
-creamy white/ yellow plaques adherent to oral mucosa
-Cracks/ ulcers around the mouth
-spotty red areas on the buccal mucosa
-burning oral pain
-loss of taste
-pain while eating or swallowing
Vaginal:
-vaginal itching or soreness
-pain during sexual intercourse
-pain/ discomfort when urinating
-abnormal vaginal discharge
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5
Q

What are the risk factors for vaginal candidiasis?

A
Pregnancy
Use of hormonal contraceptives
Diabetics
Immunosuppressed/compromised
Past or recent use of broad spectrum antibiotics
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6
Q

What are the signs of a candidiasis infection on physical examination?

A

Rash
Erythema
Visible plaques/ulcers

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7
Q

What are the appropriate investigations for a candidiasis infection?

A

Superficial smear of the lesion for microscopy: test for candida
Biopsy
Blood culture
FBC: WCC elevated indicates infection

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8
Q

What is an epidural?

A

An anaesthetic injected into the epidural space surrounding the fluid-filled sac (the dura) around the spinal cord. It partially numbs the abdomen and legs and is most commonly used during childbirth.

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9
Q

What are the indications for an epidural?

A

Provide analgesia:
- intraoperative
- postoperative
- peripartum (labour analgesia, Caesarean section)
- end-of-life settings
Can be used as the primary anaesthetic for surgeries from the mediastinum to the lower extremities

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10
Q

What are the possible complications of an epidural?

A
Drug related:
-anaphylaxis due to allergy due to anaesthetic 
Procedure related:
-back pain
-pneumocephalus (presence of air/gas in the cranial cavity)
Potentially life-threatening:
Subdural injection of LAs
Total or high spinal, infectious or aseptic meningitis
Cardiac arrest
Spinal epidural abscess
Epidural hematoma formation
Permanent neurologic injury
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11
Q

What is mastitis?

A

Inflammation of the breast with or without infection

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12
Q

What are breast abscesses?

A

A breast abscess is a localised area of infection with a walled-off collection of pus

It may or may not be associated with mastitis (as a complication)

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13
Q

What are the two types of mastitis with infection?

A

Lactational

Non-lactational

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14
Q

What is the aetiology for mastitis/ breast abscesses?

A

Infectious mastitis and breast abscesses are usually caused by bacteria colonising the skin. Cases due to Staphylococcus aureus are by far the most common.

Non-infectious mastitis may result from underlying duct ectasia and infrequently foreign material (e.g. nipple piercing, breast implant)

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15
Q

What is the epidemiology for mastitis/breast abscesses?

A

The global prevalence of mastitis in lactating women is approximately 1% to 10% but may be higher.
Breast abscess develops in 3% to 11% of women with mastitis

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16
Q

What are the presenting symptoms for mastitis/breast abscesses?

A

Fever
Decreased milk outflow (if lactational)
Breast warmth/ tenderness/ swelling/ redness (erythema)
Flu like symptoms- malaise and myalgia

17
Q

What are the signs of mastitis/breast abscesses on physical examination?

A

Breast erythema

UNCOMMON: Breast mass, fistula, nipple inversion/retraction, nipple discharge, lymphadenopathy, extra-mammary lesions

18
Q

What are the appropriate investigations for mastitis/breast abscesses?

A

1st line:
-Breast ultrasound-hypoechoic lesion (abscess), may be well circumscribed, irregular, or ill defined
-Diagnostic needle aspiration- purulent fluid indicates a breast abscess
-CMS of nipple discharge or needle aspirate- indicate infection/malignancy
(CMS- cytology, microscopy and sensitivity)
Others: pregnancy test, mammogram, blood culture

19
Q

What is the management for mastitis/breast abscesses?

A
The goal of treatment for mastitis is to provide prompt and appropriate management to prevent complications such as a breast abscess.
Lactational:
-Effective milk removal
-Antibiotic therapy
-Warm compresses
-Symptomatic relief

Non-lactational:

  • Antimicrobial therapy (observational period)
  • Supportive measures should include analgesia, if necessary.
  • For granulomatous mastitis (idiopathic granulomatous inflammation)- glucocorticosteroids
20
Q

What are the complications of mastitis/breast abscesses?

A

Breast abscesses (less than 10% of patients with mastitis)
Cessation of breastfeeding (most patients can continue to breastfeed)
Sepsis
Scarring (recurrent infections)
Functional mastectomy (breast that is unable to effectively lactate as a complication of prior tissue destruction from infection or treatment)

21
Q

What is the prognosis for mastitis/breast abscesses?

A

When treated promptly and appropriately, most breast infections, including abscess, will resolve without serious complications.
Resolution of mastitis after 2-3 days of appropriate antibiotic therapy is expected among most patients.
Lactational abscesses tend to be easier to treat than non-lactational abscesses- these are multi-factorial and have a greater risk of becoming chronic

22
Q

What is polycystic ovary syndrome (PCOS)?

A

A syndrome characterised by:
-oligomenorrhoea/amenorrhoea
-hyper-androgenism (clinical symptoms or biochemical)
Usually associated with: obesity, insulin resistance and an increased risk of developing type 2 diabetes

23
Q

What is the aetiology of PCOS?

A

Environmental factors:
related to diet and development of obesity
Genetic determinants:
genes regulating gonadotrophin, insulin and androgen synthesis, secretion and action, weight and energy regulation

24
Q

What are the risk factors for PCOS?

A

FHx of PCOS
Premature adrenarche
Weaker risk factors: obesity, low birth weight

25
Q

What is the epidemiology for PCOS?

A

PCOS is the most common cause of infertility in women
Affects 6–8% of women
Symptoms generally start at the age of puberty

26
Q

What are the presenting symptoms of PCOS?

A
Menstruation:
Irregularities (oligomenorrhoea or amenorrhoea)
Dysfunctional uterine bleeding
Infertility
Hyperandrogenism:
Hirsutism (male pattern hair growth)
Male-pattern hair loss
Acne
27
Q

What are the signs of PCOS on physical examination?

A
Hirsutism, male pattern hair loss and acne
Acanthosis nigricans (sign of severe insulin resistance-HYPERINSULINAEMIA): velvety thickening and hyperpigmentation of the skin of axillae or neck, more commonly seen in obese women
28
Q

What are the appropriate investigations in PCOS?

A

-Blood tests:
Raised LH levels
Raised LH: FSH ratio (>3)
Raised Testosterone, androstenedione and DHEA-S
Reduced sex hormone binding globulin (SHBG)
-Exclude other endocrine causes:
Serum prolactin (hyperprolactinaemia)
Thyroid function tests (hypo/hyperthyroidism)
17OH-progesterone (congenital adrenal hyperplasia), Cushing’s syndrome
Impaired glucose tolerance test/DM type 2: (fasting glucose, HbA1c)
-Transvaginal USS:
Twelve or more follicles in each ovary, measuring 2–9 mm and/or raised ovarian volume >10 mL (CYSTS)

29
Q

What are the values that diabetes can be defined at?

A

Fasting glucose > 7mmol/L

2 hour glucose tolerance > 11mmol/L