RA Other

Question 1

Aetiology of RA

Answer 1

F>M

Peak age 50-55years

Question 2

Risk factors for RA

Answer 2

Genetics:

• FH
• HLA-DR4
• HLA-DR1
• PTPN22

Mutations in:

• CD28
• CD40

Environmental factors:

• Smoking
• Bronchial stress
• Infectious agents

Question 3

Blood results in RA

Answer 3

ESR increase
CRP increases
Platelets increase
RF +ve

Question 4

Lungs extra-articular s/s in RA

Answer 4

Pleural Disease,
Interstital Fibrosis,
Bronchiolitis,
Obliterans,
Organising Pneumonia

Question 5

Cardiac extra-articular s/s in RA

Answer 5

Ischaemic heart disease,
Pericarditis,
Pericardial effusion

Question 6

Eye extra-articular s/s in RA

Answer 6

Scleritis,
Episcleritis,
Scleromalacia,
Keratoconjunctivitis

Question 7

Other extra-articular s/s in RA

Answer 7

Carpal Tunnel, splenomegaly (Felty’s syndrome)
Osteoporosis,
Amyloidosis,
Sjogren’s syndrome

Question 8

Xrays signs in RA

Answer 8

Periarticular osteoporosis,
Soft tissue swelling, 
Bony erosion,
Decrease joint space,
Subluxation,
Carpal instability