TCRs Flashcards
1
Q
2 types of TCRs
A
1) alpha-beta (“conventional T cells”): recognize peptides shown by MHC
2) gamma-delta (minority): recognize antigens directly or when presented by CD1
2
Q
structure of a TCR
A
alpha & beta chain
3
Q
TCR associated proteins
A
2 pairs of CD3 chains (one epsilon/gamma pair, one epsilon/delta pair) + 1 homodimer of zeta chains.
CD3s and the zeta chains have long tails into cytoplasm, associated with ITAM signaling molecules.
4
Q
how is TCR diversity created?
A
VDJ recombination:
alpha-beta has 10^6 possibilities, gamma-delta has 10^3 possibilities
