7-Disorders of the immune System 2 Flashcards
humoral immunity
antibodies made by B lymphocytes/plasma cells
other names for neutrophils
granulocytes, polymorphonuclear granulocytes (PMNs, Polys)
what is a band cell?
- an early neutrophil
- the level of these will rise in bacterial infections
which cellular markers identify T-lymphocytes?
CD2, CD3
types and percents of peripheral lymphocytes
- B Lymphocytes 10-20%
- Natural Killer cells: 10-15%
- 60-70% T-lymphocytes (also in lymph nodes and spleen)
- 60% of those are CD4+ and 30% are CD8+ (of CD3+? cells)
T cell antigen receptor binds to:
CD3 complex
TCR
somatic gene rearrangements (?)
T cell proliferations:
- (mono)clonal=neoplastic (potential for malignancy)
- polyclonal=non-neoplastic
CD4+ helper T cells
- secrete cytokines
- 60% of CD3+ T cells
- TH1 induce cellular immunity
- TH2 induce humoral immunity
- CD4 bind MHC class II for antigen presentation
CD8+ suppressor T cells
- cytotoxicity
- 30% of CD3+ T cells
- CD8 binds MHC class I for Ag presnetation
CD4/CD8 ratio
~2:1
-HIV infection destroys CD4 cells; ratio <1
where are B lymphocytes predominately found?
bone marrow, lymph nodes, spleen, tonsils
When B lymphocytes are stimulated by antigens, =
they form plasma cells
What are the CD markers for B cells?
CD19, CD 20, CD21
what virus infects B cells? and what disease does it cause?
-what medication is used to treat it?
- EBV
- infectious mononucleosus
- rituximab (anti-CD20 against B cell malignancies)
