Cardiac long case Flashcards

1
Q

Acute coronary syndrome history

A

o Presence of chest pain, at rest or with exercise, emotion; intensity of pain, prolonged length of pain

o Diagnosis on ECG and troponin

o Requirement of thrombolysis

o Presence of heart failure and ICU

o Stent insertion

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2
Q

Coronary stent history

A

o Diagnosis on stress testing, and/or stable angina symptoms

o Angiogram – single or multiple arteries

o Antiplatelet therapy o Follow up echocardiogram

o Chest pain post nstemi, repeat angiogram

o Stent thrombosis, coronary artery dissection

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3
Q

Coronary bypass history

A

o Diagnosis stress testing following stable angina, angiogram results o Sternotomy vs. minimally invasive o Bypass grafts, how many, saphenous veins, radial arteries, mammary arteries ?venous insufficiency o Subsequent chest pain and follow up angiogram o Use of aspirin

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4
Q

Long term management - CAD (non pharm)

A

o Cardiovascular rehabilitation program

o Regular exercise

o Medication adherence

o Regular cardiologist and GP review

o Alcohol avoidance, smoking cessation

o Green leafy vegetables

o Coronary risk factor management

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5
Q

Coronary artery disease risk factor managment

A

o Dyslipidaemia – prior cholesterol, HDL and LDL levels

 Statins or fibrates

 Statin intolerance – myositis

o Hypertension – initial diagnosis, ongoing monitoring

 Medications

 Complications monitoring TTEs, renal function, regular ophthalmology testing by GP

 Low salt diet, alcohol, green leafy vegetables

o Smoking

 Amount, what exactly

 Awareness of association

 Attempts to quit

o T2DM

o Other factors, CKD, chronic inflammatory disease, obesity, stress

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6
Q

Precipitants for acute heart failure

A

o Poor adherence to fluid restriction

o NSTEMI/STEMI

o Intercurrent infection

o PE

o Pregnancy

o Thyroitoxicosis

o Post-operative setting

o Anaemia and acute haemorrhage

o Arrythmias

o Drugs – NSAIDs, amitriptyline, pioglitazones

o Sleep apnoea/ILD/COPD for RHF

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7
Q

Systolic heart failure causes

A

 IHD

 Alcohol

 Valvular disease

 Congenital/idiopathic dilated cardiomyopathy

 Hypertrophic cardiomyopathy

 Tachyarrhythmic cardiomyopathy

 Viral cardiomyopathy

 Noradrenaline induced cardiomyopathy – amphetamines, tachosubo cardiomyopathy

 Familial myopathies – fredericks ataxia, myotrophica dystonica

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8
Q

Causes of diastolic failure

A

o Diastolic failure in the setting of hypertension, T2DM, age

o Restrictive cardiomyopathy

 Amyloidosis

 Haemochromatosis

 Metastatic disease

 Lipid/glycogen storage diseases

 Loeffler’s syndrome

o Constrictive pericarditis

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9
Q

Management of heart failure

A

o Medications – beta blockers, ACEI, spironolactone, frusemide

o Management of precipitants – avoid drugs, manage and treat anaemia, thyrotoxicosis, management of arrythymias, PEs, antibiotics etc.

o General measures – fluid restrict, low sodium diet, daily weights, heart failure action plan o Heart failure rehabilitation program

o Influenza and pneumococcal vaccinations

o Device therapy AICDs, biventricular pacing

o Regular follow up and monitoring – TTEs, GP reviews, regular UECs, LFTs, regular INRs if on warfarin for mechanical valves, mitral stenosis o Heart transplantation

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10
Q

Contraindications to transplant

A

o Age >65

o Active infection with HBV, HCV, HIV

o Active malignancy within 5 years

o Pulmonary hypertension with > 5 wood units

o Poor social supports

o Ongoing drinking or smoking

o Intractable renal or liver failure

o Diagnosis of degenerative brain disease

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11
Q

Pre-transplant work up

A

o Cardiopulmonary exercise testing

o Pulmonary function tests FEV1, FVC, DLCO

o CXR and ECG

o TTE and coronary angiogram

o FBE, UEC, urinary protein/creat, HBA1c TFT, iron studies, serum immunoglobulins and electrophoresis, ANA, ANCA, ENA, C3/4, coags, lupus anticoagulant o

LFTs renal and liver USS

o Sleep study

o DEXA scan

o Cancer screening – PSA, PR exam, pap smears, mammography/breast USS, endometrial USS

o HIV, HBV and HCV screening, quantiferon gold test, CMV, EBV serology, other tests directed by travel history

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12
Q

Post transplant work up

A

o Immunosuppression regime

o Regular angiogram and Bx for coronary vascular arteriopathy

o Graft rejection

 Acute, chronic o Infections – post operatively, 3 months, 1 year o Regular appointments o Metabolic  Osteoporosis  HTN  T2DM secondary to immunosuppressants  Dyslipidaemia

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13
Q

Atrial fibrillation

A
  • Diagnosis – incidental, symptoms post stroke
  • Anticoagulation CHADS2Vasc, HASBLED scores
  • History WPW
  • Prior electrophysiological studies and ablation
  • Prior maze therapy or left atrial appendage removal – watchman device (on aspirin) - Prior stroke, large atria - TTE
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14
Q

HASBLED score

A

hypertension, age >65, anti-coagulant meds, alcohol use, stroke, liver and renal disease

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15
Q

CHADSVASC score

A

CCF, HTN, age >65, stroke, vascular disease, sex

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16
Q

Indications for pacemaker

A

o Complete heart block with

 Symptomatic bradycardia

 Cardiac failure

 Arrhythmias that require treatment with drugs to slow conduction

  • Asystole of more than 3 seconds with escape <40bpm
  • Confusion improvement with temporary pacing

o second degree heart block with symptomatic bradycardia

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17
Q

Automated implantable cardioverter-defibrillator device indications

A

o Primary prophylaxis

 MI and persisted LVEF<30% after 40 days

 LVEF <35% and dilated cardiomyopathy

o Secondary prevention

 Those candidates for CRT device HF w/ intraventricular conduction delay >120ms

 Sustained VT or VT to VF w/ structural heart disease that are not amenable to ablation/refractory

 Congential long QT with recurrent symptoms and torsades de pointes

 Hypertrophic cardiomyopathy, Brugada, catecholaminergic polymorphic VT and arrhythmogenic right ventricular cardiomyopathy

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18
Q

Softer indications for pacemaker

A
  • Softer indications for pacemaker

o Asymptomatic CHB rate >40

o Symptomatic second degree heart block without demonstrated symptomatic bradycardia

o Bifascicular or trifascicular block with syncope of unclear indication

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19
Q

Risk factors for AF

A

o Thyrotoxicosis

o OSA

o etOH

o Mitral valve disease

o Post operative setting

o COPD

o PE

o Hypertension

o Atrial septal defect

o Age

20
Q

Infective endocarditis history

A
  • History, investigations, complications management
  • Differentials, severity indices, adherence/insight, tolerance
  • Risk factors for infective endocarditis

o Intravenous drug use

o Prior infective endocarditis

o Endoscopic, dental procedure or operation

 Antibiotic prophylaxis

o Heart operation

o Antibiotic allergies

o Organ transplantation on immunosuppression

o Steroid use and other immunosuppression

o Joint and vascular prostheses

o Weight loss/night sweats/loss of weight loss of appetite

o TTE results

21
Q

Risk factors for infective endocarditis

A

o Prosthetic valve – mechanical or tissue o Mitral disease

 Mitral repair

 Mitral regurgitation

 Mitral stenosis

o Aortic disease

 Aortic regurgitation

 Aortic stenosis

o Congenital

 Bicuspid aortic valve

 Persistent ductus arteriosus

 Ventricular septal defect

 Coarctation of aorta

 Pacemaker leads

22
Q

Microbial infections causing IE

A

o Prostate/UTI and S. faecalis

o Colonic polyps and S. bovis

o Oral procedures and S. viridians (subacute)

o IV lines, IVDU

– S areus

o Prosthetic valves

-S. epidermidis, S. areus

23
Q

Indications for valve replacement

A

o Valvular dysfunction causing heart failure, AR most severe

o Resistant organisms

o Positive blood cultures despite treatment

o Paravalvular infections causing bradycardia

24
Q

Factors in IE indicating poor prognosis

A

o Shock

o CCF

o Age

o Aortic valve involvement

o Multiple valves

o Culture negative IE

o Delay in treatment

o Prosthetic valves

o S. aureus, fungal, and gram negative (rare)

25
Q

Differentials for IE

A

o Cardiac thrombus

o Atrial myxoma

o Occult malignancy

o Polyarteritis nodosa

o Post strep glomerulonephritis

o PUO

26
Q

Indications for prophylaxis

A

o Complex congenital HD

o Partially repaired congenital heart disease w/ synthetic material

o Prior infective endocarditis

o Prosthetic heart valves

o Cardiac transplant with valve dysfunction

27
Q

Prophylaxis regime

A

o Ampicillin 2g or clindamycin 600mg oral 1 hour prior

o IV gentamicin with high risk cases

28
Q

Hyperlipidaemia - Familial hypercholesterolaemia

A

o Autosomal dominant

o Heterozygous AMI 30-40, homozygous in 20s (AMI, even aortic stenosis)

o Tendon xanthomas, arcus corneus

29
Q

Hyperlipidaemia- dysbetaproteinaemia

A

o Palmar xanthomata

o Coronary artery disease increase particularly in T2DM, obesity and hypothyroidism

o Often strong peripheral vascular disease history

30
Q

Hyperlipidaemia - Familial hypertriglyceridaemia

A

o Eruptive painful xanthomata on elbows buttocks

o Often associated with pancreatitis, obesity, hyperuricaemia

31
Q

Hyperlipidaemia -secondary causes

A

nephrotic syndrome, hypothyroidism, HRT, etOH

32
Q

Measures of heart function - history

A
  • Dyspnoea and exercise tolerance (ET)
  • Severity of orthopnoea and pillow requirement
  • Paroxysmal nocturnal dyspnoea and sleep disturbance
  • Frequency of hospital admissions
  • Number of heart failure medications
  • Chest pain with walking and ET
33
Q

Measures of heart function - examination

A
  • End organ damage

o Cyanosis and oxygen requirements

o Oligouria/anuria

o Delirium

o Hepatitis

  • Raised jugular venous pressure
  • Loud and prolonged murmurs
  • Displaced apex beats, thrusting or heaving apex beats (dilated and hypertrophic cardiomyopathies)
  • Parasternal heaves (RVF)
  • Absent S1 or loud S2
34
Q

Measures of heart function - investigations

A
  • TTE – ejection fraction

regurgitant fraction (MR, AR)

valve area and gradient(AS,MS)

E/E’ (HFpEF)

left atrial index (HFpEF)

right ventricular systolic pressure (pulmonary hypertension)

  • LVH, LBBB/RBBB, AF etc.
35
Q

Antihypertensive agents - beta-blockers

  1. Contraindications and cautions to beta-blockers
A
  1. Beta blockers interfere with glucose control and may worsen blood lipids; may also cause bradycardia, hypotension,depression and cold peripheries

They are contraindicated in peripheral vascular disease, Caution in COPD/asthma

Good in patients with CCF, IHD, history of gout and suitable in pregnancy

36
Q

Anti-hypertensive agents - ACEI and ARBs

Cautions and contraindications

Uses

A

May cause angio-oedema, cough, postural hypotension, hyperkalaemia, worsening of renal failure and first dose hypotension (with low sodium diets and diuretics)

ARBs do not cause cough

Wait until diuresis is complete before starting

Good for T2DM, IHD, CCF, PHx gout, dyslipidaemia, and diabetic nephropathy

37
Q

Antihypertensive agents - thiazide diuretics

Cautions and contraindications to thiazide diuretics

Uses

A

Can cause hyperlipidaemia, hyperglycaemia, thrombocytopaenia and gout

Do not use in patients with gout, dyslipidaemia or poorly controlled T2DM

38
Q

Antihypertensive agents - Calcium channel blockers

cautions and contraindications

A

May cause bradycardia and precipitate heart block; may also cause headaches, sweating, palpitations and ankle oedema

Use in stable angina, peripheral vascular disease, IHD, dyslipidaemia, gout, T2DM

Caution in CCF

39
Q

Antihypertensive agents - Alpha blockers and other peripheral and central vasodilators

  1. Cautions, contraindications and uses of alpha blockers
  2. Cautions contraindications and uses of perpherial vasodilators
  3. Cautions, contraindications and uses of central vasodilators
A
  1. May cause severe postural hypotension; for use in peripheral vascular disease, gout pts , pregnancy, and BPH
  2. minoxidil - causes sodium and water retention, peripheral oedema/pericardial effusion and hypertrichosis
  3. Hydralazine used in pregnancy and African-American populations; can cause SLE and ANCA vasculitis;
40
Q

Differentials for hypertension

A

Essential (95%)

Obesity

OSA

Alcoholism

Medications (OCP, corticosteroids, cyclosporin)

Anxiety and pain

Renal artery stenosis

Parenchymal renal disease

Hyper and hypothyroidism

Acromegaly

Cushing’s syndrome

Conn’s syndrome (primary hyperaldosteronism)

Phaeochromocytoma

Coarctation of aorta

Polycythemia vera

Raised intracranial pressure

Acute intermittent porphyria

41
Q

Examination for hypertension

A

HR, RR

Radiofemoral delay (coarctation)

BP, including postural drop and opposite arm (coarctation)

Tremor

Palmar erythema and conjunctival pallor

Fundoscopy (hypertension), EM exam (diabetes), lid lag, chemosis/conjunctival oedema (thyroid eye disease)

Hand, jaw, ear and nose size (acromegaly)

Large tongue (acromegaly, hypothyroidism)

Buffalo hump, moon facies, striae, bruising (Cushing’s)

Hirsuitism (adrenal carcinoma, CAH)

Cervical lymphadenopathy, swallowing, goitre and thyroid bruit (hyperthyroidism)

Neck circumference (OSA)

carotid bruit, AAA, femoral bruit, dorsalis pedis pulses, tibial pulses, cap. refill and sensation (PVD, T2DM)

Cardiovascular exam - lateral apex beat (IHD), MR

Abdominal exam - HSM (acromegaly), masses (adrenal carcinoma, PKD), renal bruit (renal artery stenosis)

Proximal limb weakness (Cushing’s, hypothyroidism)

Reflexes (hyper/hypothyroidism)

42
Q

Management of Hypertension

  1. Indications for treatment
  2. Lifestyle modifications
  3. Drug combinations
  4. Investigation
A
  1. Treat with antihypertensives immediately if signs of end organ damage and SBP >160 or DBP >100 and systolic >200 mmHg; otherwise 24hr BP monitor and/or observe for 3-6 months w/ lifestyle modifications
  2. Reduce alcohol intake and quit smoking, Exercise 3-4x per week for 20-30mins at a time, salt restriction <4g/day, High green leafy vegetable intake
  3. Commence w/ thiazide (if >65 w/o CI) or ACEI/ARB (if metabolic syndrome); consider ACEI/ARB as a second line and calcium channel blocker as a 3rd line
43
Q

Management of cardiac failure

  1. Acute
  2. Chronic
A
  1. Treat respiratory distress IV frusemide, O2, CPAP
    1a. Consider GTN if hypertensive and no previous RHF
    1b. Consider the use of nesiritide (recombinant BNP agonist)
    1c. If hypotensive will require inotropes (levosimendan or dobutamine) w/ frusemide (for reducing cardiac preload) +/- aortic balloon pump may be required
    1d. Investigate cause -ECG, CXR, ABG, FBE, UEC +/- Swan Ganz catheter
  2. Beta blocker, ACEI if EF <40%, frusemide, spirinolactone, cardiac resynchronisation if QRS >120ms, ACID, warfarin if mural thrombus, digoxin for AF, LVAD
44
Q

**Differentials for diastolic HF

A

Chronic HTN

IHD

Persistent/recurrent tachyarrthymias

T2DM

Restrictive cardiomyopathy - amyloidosis, haemochromatosis, sarcoidosis

Hypertrophic obstructive cardiomyopathy

Constrictive pericarditis

45
Q

Territories for Myocardial Infarct

A

Anterior MI - V1-V6 LAD, distal, inferior reciprocal changes

Septal MI - V1-4, Loss of Q in V5-6 LAD - septal branches

Lateral MI I, aVL, V5-6 II, III, aVF Left Circumflex artery

Inferior MI II, III, aVF I, aVL Right coronary artery (80%) or Right circumflex

Posterior MI V7-9 High R in V1-3 with ST depression V1-3 >2mm Right Circumflex artery

Right Ventricle MI V1, V4R I, aVL Right Coronary Artery