Lymphoma and Leukemia - Pediatrics Flashcards

1
Q

What is the leading cause of death by disease past infancy among children in the United States?

A

Cancer

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2
Q

What is the most common types of cancer diagnosed in chidlren ages 0-14 y/o in the US?

A

Leukemias

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3
Q

What is the most common types of cancer diagnosed in adolescents 15-19 y/o; what is a common infectious agent implicated?

A

Lymphomas; EBV

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4
Q

Which type of lymphoma is the most common malignancy in age group 15-19 y/o?

A

Hodgkin lymohoma

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5
Q

What are B-symptoms?

A
  • Unexplained fever 39°C
  • Wt. loss >10% total BW over 6 months
  • Drenching night sweats
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6
Q

Any pt with persistent, unexplained LAD unassociated with an obvious underlying inflammatory or infectious process should get what?

A

A CXR to rule of mediastinal mass before undergoing LN biopsy

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7
Q

What are the clinical manifestations of Wiscott-Aldrich Syndrome; how is it inherited; what is it a risk factor for?

A
  • X-linked recessive
  • Recurrent sino-pulmonary and ear infections
  • Severe atopic dermatitis
  • Bleeding –> 2’ to significant thrombocytopenia
  • Risk factor for NHL***
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8
Q

Burkitt lymphoma commonly manifests in pediatric populations how?

A
  • Abdominal (sporadic type)

or

  • Head and neck dz (endemic type) w/ involvement of BM or CNS
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9
Q

Which genetic trisomy associated with both ALL and AML?

A

Trisomy 21

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10
Q

Which type of leukemia constitutes 97% of all childhood leukemias?

A

Acute leukemia

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