AMITRAZ (FORMAMIDINE) MAO-inhibitors

Question 1

AMITRAZ MAO-inhibitors Substances

Answer 1

• Octopamine, dopamine, noradrenaline, inhibition of serotonine reuptake
• Energy demand of honey bees
• Temperature! (10-12 0C, but opt. 14-18 0C)

Question 2

AMITRAZ MAO-inhibitors Works

Answer 2

Mechanism of action: MAO-inhib. + α2 agonist
Kinetics: moderate absorption (p.o. 13% > dermal), half-life 23 hours in dogs
Spectrum: MANGE MITES, DEMODEX, ticks
Application: 0,025% solution, collar, impregnated strips

Question 3

AMITRAZ MAO-inhibitors Use

Answer 3

Narrow therapeutic index: Eq, Chihuahua, Fe (small doses)
Oral administration is more toxic sedation, bradycardia, hypothermia, emesis, hyperglycaemia (not in DM) storage: light, air!
Antidote: atipamezole 0,05 mg/kg (half-life!)