Obesity

Question 1

What BMI is classed as overweight?

What is classed as obese?

Answer 1

> 25

> 35

Question 2

What endocrine conditions may cause obesity?

Answer 2

Hypothyroidism

Cushing’s

Question 3

Health risk of obesity:

• CVD
• Metabolic syndrome
• Cancer
• Respiratory
• Gallbladder
• Bones

Answer 3

HTN
High cholesterol
IHD
Stroke

T2DM, NAFLD

Breast
Colorectal
Endometrial
Cholangiocarcinoma

Obstructive sleep apnoea
Obesity hypoventilation syndrome

Gallstones

Osteoarthritis

Question 4

Management:

First-line
Second-line
Third-line
Fourth-line

Answer 4

Weight-loss diet - sustained weight loss

Regular exercise >150/wk

Orlistat - OTC medication used to help people lose weight.

Bariatric surgery

Question 5

Orlistat:

MOA

Indications

Obvious side effects if you no MOA

Answer 5

Lipase inhibitor so reduces GI absorption of fat, therefore, reducing weight

BMI >30 and failure of the behavioural approach

Steattorhoea and anal leakage
Flatulence
Abdominal distention and pain
Faecal urgency/incontinence