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General Gynecology > Recurrent pregnancy loss > Flashcards

Recurrent pregnancy loss Flashcards

1
Q

What is the definition of spontaneous abortion?

A

Loss prior to 20 weeks or below 500 g

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2
Q

What is the definition of recurrent pregnancy loss?

A

Two or more consecutive spontaneous miscarriages

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3
Q

What is the definition of anembryonic pregnancy?

A

empty gestational sac at 4-5 weeks of pregnancy

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4
Q

What is the definition of yolk sac misscariage?

A

Yolk sac present by no embryo by 5-6 weeks

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5
Q

What is the definition of fetal demise?

A

fetus with cessation of cardiac activity after 10 weeks

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6
Q

What is the definition of early pregnancy loss?

A

nonviable, intrauterine pregnancy prior to 13 weeks gestation

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7
Q

Crown rump length of ____mm or greater and no heart beat is diagnostic of early pregnancy failure.

A

7

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8
Q

Mean Sac diameter of ___mm or greater and no embryo present is diagnostic of early pregnancy failure.

A

25

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9
Q

Absence of embryo with heartbeat ____ days or more after scan showed gestational sac WITHOUT yolk sac is diagnostic of early pregnancy failure.

A

14

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10
Q

Absence of embryo with heartbeat _____ days or more after scan showed gestational sac WITH yolk sac is diagnostic of early pregnancy failure.

A

11

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11
Q

What medications should be given preop for a D&C for missed SAB?

A

Doxycyline 200 mg

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12
Q

What is the recommended regimen for medical management of missed SAB?

A

Misoprostal 800 mcg vaginally

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13
Q

What medication and dose can be added to misoprostal to improve the efficacy for missed SAB?

A

Mifepristone 200 mg 24 hrs prior to Misoprostal

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14
Q

Misscariage affects what percentage of pregnancies?

A

12-15%

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15
Q

What is the rate of recurrent pregnancy loss?

A

1-2%

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16
Q

What is the most common cause of recurrent pregnancy loss?

A

Chromosomal abnormalities

17
Q

What is the rate of miscarriage in women < 30 years?

A

25%

18
Q

What is the rate of miscarriage in women 31 - 35 yrs?

A

28%

19
Q

What is the rate of miscarriage in women 36 - 39 yrs?

A

33%

20
Q

What is the rate of miscarriage in women > 40yrs

A

52%

21
Q

What percentage of 1st trimester pregnancy loss is attributed to chromosomal abnormalities?

A

> 75%

22
Q

What is the most common Trisomy associated with SAB?

A

Trisomy 16

23
Q

What is the most common chromosomal abnormality resulting in SAB?

A

Trisomies

24
Q

What is the second most common chromosomal abnormality resulting in SAB?

A

Monosomy X, Turners

25
Q

What is the most common type of genetic mutation associated with parental chromosomal abnormalities?

A

balanced translocation

26
Q

What is the most common congenital uterine anomaly associated with recurrent pregnancy loss?

A

Septate Uterus

27
Q

What is the best treatment for recurrent pregnancy loss associated with a septate uterus?

A

Hysteroscopic septoplasty

28
Q

Which type of fibroids carry risk of miscarriage?

A

Submucosal and intramural

29
Q

In a patient with previous curretage for septic SAB who has recurrent pregnancy loss, what would you anticipate the cause?

A

Asherman’s syndrome

30
Q

What percentage of women with recurrent pregnancy loss have positive antiphospholipid antibodies?

A

5 - 20%

31
Q

What three antiphospholipid antibodies can cause recurrent pregnancy loss?

A

Lupus anticoagulant, Anticardiolipin antibody, Anti-B2 Glycoprotein I antibody

32
Q

True/False: subclinical hypothyroidism cause recurrent pregnancy loss

A

True

33
Q

What two infectious organisms are associated with Recurrent pregnancy loss?

A

Ureaplasma and Mycoplasma

34
Q

Do obese women have a higher rate of SAB?

A

Yes

General Gynecology (11 decks)

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