Neurological

Question 1

Phrase to remember antiepileptics & mechanisms of action?

Answer 1

AS carbs raise LBs try protein 2 amp-up per GP who also recommends calcium, but thalamus milk sucks.
TROLZ are so dumb. VP LC (Vice President Elsie) is so dumb 2. You need the gift of the GAB to be on TV.

Question 2

Acetazolamide MOA?

Answer 2

AS carbs raise…
Inhibits carbonic anhydrase -> accumulation of carbonic acid -> decreased pH
Accumulation of CO2
Increases excretion of HCO3− (as well as Na, Cl & H2O)

H2CO3 ⇌ H2O + CO2
H2CO3 ⇌ HCO3− + H+

Question 3

Sulthiame MOA?

Answer 3

AS carbs raise…
Inhibits carbonic anhydrase &amp leading to carbonic acid accumulation and intracellular acidosis of central neurons to reduce the frequency of action potentials and epileptiform bursts

Question 4

Levetiracetam MOA?

Answer 4

…LB, try protein 2…

Binds synaptic vesicle protein 2A to modulate neurotransmitter release.

Question 5

Brivaracetam MOA?

Answer 5

…LB, try protein 2…

Binds synaptic vesicle protein 2A to modulate neurotransmitter release.

Question 6

Perampanel MOA?

Answer 6

…amp-up per…

Post-synaptic AMPA glutamate receptor antagonist.

Question 7

Gabapentin MOA?

Answer 7

…GP who also recommends a 2D calcium…
Binds alpha-2-delta protein subunit of high threshold voltage-dependent calcium channels, reducing calcium influx and neurotransmitter release.

Was designed to mimic GABA, but doesn’t actually bind to GABA receptors.

Question 8

Pregabalin MOA?

Answer 8

…GP who also recommends calcium…
Binds alpha-2-delta protein subunit of high threshold voltage-dependent calcium channels, reducing calcium influx and neurotransmitter release.

Structurally related to GABA, but doesn’t bind GABA receptors.

Question 9

Ethosuximide MOA?

Answer 9

But thalamus milk sucks.

Reduces low threshold voltage-dependent calcium conductance in the thalamus.

Question 10

Topiramate MOA?

Answer 10

TROLZ are so dumb.

Blocks voltage-dependent sodium channels.

Question 11

Rufinamide MOA?

Answer 11

TROLZ are so dumb.

Blocks voltage-dependent sodium channels.

Question 12

Oxcarbazepine MOA?

Answer 12

TROLZ are so dumb.

Blocks voltage-dependent sodium channels.

Question 13

Lacosamide MOA?

Answer 13

TROLZ are so dumb.

Blocks voltage-dependent sodium channels.

Question 14

Zonisamide MOA?

Answer 14

TROLZ are so dumb.

Blocks voltage-dependent sodium channels.

Question 15

Valproate MOA?

Answer 15

VP LC is so dumb too.

Blocks voltage-dependent and use-dependent sodium channels.

Question 16

Phenytoin MOA?

Answer 16

VP LC is so dumb too.

Blocks voltage-dependent and use-dependent sodium channels.

Question 17

Lamotrigine MOA?

Answer 17

VP LC is so dumb too.

Blocks voltage-dependent and use-dependent sodium channels.

Question 18

Carbamazepine MOA?

Answer 18

VP LC is so dumb too.

Blocks voltage-dependent and use-dependent sodium channels.

Question 19

tiaGABine MOA?

Answer 19

You need the gift of the gab to be on TV.
Inhibits neuronal reuptake of GABA.
(To increase GABA-mediated inhibition.)

Question 20

viGABatrin MOA?

Answer 20

You need the gift of the gab to be on TV.
Irreversibly inhibits GABA aminotransferase, which increases brain concentrations of GABA.
(And GABA-mediated inhibition.)

Question 21

Phrase to remember Parkinson’s drugs and their classes?

Answer 21

A man entered then left.
Dope bro. A Pommy roped in a rotten cabbage pram.
And he tried to hex the Benz.
May be a rascal, safer in a cell.

Amantadine, entacapone, levodopa
Dopamine agonists: bromocriptine, apomorphine, ropinirole, rotigotine, cabergoline, pramipexole
Anticholinergics: trihexphenidyl, benztropine
MAO-B inhibitors: rasagiline, safinamide, selegiline

Question 22

Phrase to remember Alzheimer’s drugs and their classes?

Answer 22

Nevermind Aunt Agony, my man Colin raced a gal down to the river.

NMDA antagonist: memantadine
Anticholinesterases: galantamine, donepezil, rivastigmine