ACE inhibitors

Question 1

ACE inhibitors end in? List them

Answer 1

“pril” CLER… Captopril, Lisinopril, Enalapril, Ramipril

Question 2

Mech of action of ACE inhibitors?

Answer 2

Inhibit conversion of angiotensin I to angiotensin II and degrade bradykinin (a potent bronchodilator)

Question 3

ACE inhibitors increase renal blood flow (RBF) without changing GFR.. this results in?

Answer 3

decrease filtration fraction

Question 4

Major use of ACE inhibitors?

Answer 4

Treat HTN in CHF patients

Question 5

Which ACE inhibitor is renoprotective in diabetes?

Answer 5

Captopril; it increases synthesis of prostaglandins in vascular and renal endothelium

Question 6

This ACEI is a prodrug given IV for HTN emergencies

Answer 6

Enalapril

Question 7

This ACEI is a lysine derivative of enalapralit and is renoprotective

Answer 7

Lisinopril

Question 8

This ACEI has a long half life and is given daily

Answer 8

Ramipril

Question 9

Side effects of ACEI

Answer 9

hypotension, dry cough, hyperkalemia, angioedema, fetotoxicity