medulloblastoma Flashcards
1
Q
what is age group diagnosed with medulloblastoma
A
age <9 years
2
Q
what percent present with metastatic disease
A
40%
3
Q
what are tumor syndromes associated
A
li fraumeni, Gorlin, turcot,
4
Q
what are three main types of histologic medulloblastoma
A
classic, desmoplastic, large cell anaplastic
5
Q
which gene associated with desmoplastic/ nodular
A
SHH, mostly infant and young children
6
Q
which has worse prognoss
A
group 3 which has mostly large cell component and MYC mutations
7
Q
how is ATRT differentiated
A
INI1 mutation
