Multiple Endocrine Neoplasia (MEN) Flashcards
1
Q
Definition of MEN?
A
Hormone-producing tumours present in multiple organs
2
Q
Heritability of MEN?
A
Autosomal dominant
3
Q
Types of MEN?
A
MEN 1
MEN 2
MEN 3 or 2B
4
Q
Where is the mutation in MEN 1?
A
Menin gene on chromosome 11
5
Q
Where is the mutation in men 2?
A
RET gene on chromosome 10
6
Q
Features of MEN 1?
A
3 Ps
- Pituitary (prolactinoma, acromegaly, adrenal, carcinoid tumours)
- Parathyroid adenoma/hyperplasia
- Pancreas (insulinoma, gastrinoma)
7
Q
Features of MEN 2?
A
TAP
- Thyroid - medullary thyroid cancer (always in MEN2)
- Adrenal - phaeo (50%)
- Parathyroid hyperplasia
8
Q
Features of MEN 3/2B?
A
MEN 2 (thyroid carcinoma + phaeo) but without hyperparathyroidism
Also has mucosal neuromas (bumps on lips/cheeks/tongue/eyelids) and a Marfanoid appearance
9
Q
Process of MEN diagnosis establishment?
A
Endocrine symptoms Systemic symptoms (hypertension, weight changes, abdominal pain, headache)
10
Q
Investigations in MEN?
A
Tests for endocrine causes of symptoms
- remember metanephrine test for phaeo
