Lecture: Neurogenetic basis of Behaviour

Question 1

What can you see with a QTL mapping?

Answer 1

Quantative trait locus, to see a regression analysis for correlation of phenotype with locus/loci.

Question 2

What is the difference in UBE3a expression between angelman syndrome and praderwillisyndrome?

Answer 2

PWS: maternal pws region is NOT silenced –> Excessive weight gain.
AS: paternal as region is NOT silenced –> non-verbal

HEALTHY SUBJECTS:

• Maternal pws region is always silent
• Paternal as region always silent

Question 3

How does the stress negative feedback loop work?

Answer 3

At risk genotype when promotor region creates an inability to methylate.

Question 4

What is a denovo mutation?

Answer 4

When a gene in the germ cell, or in the beginning phase of development after fertilization, is mutated. It being the first in the family to occur.