Kaposi Sarcoma

Question 1

Has what cell origin

Answer 1

Endothelial cell origin

Question 2

linked w what type of infection?

Answer 2

HHV8

Question 3

4 clinical variants

Answer 3

Classic KS, endemic African KS, immunosuppressive therapy-related KS,
HIV/AIDS-related KS.

Question 4

systemic involvement

Answer 4

GI and lungs

Question 5

African endemic type KS has what age prediliction and gender

Answer 5

young adults, mean age 35;
young children, mean age 3 years.

Males > females

Question 6

what type of KS ,

Most common in solid transplant recipients as well as individuals treated chronically with immunosuppressive drugs. arises 16.5 months average after transplantation

Answer 6

Iatrogenic immunosuppression type

Question 7

Risk of KS in HIV people compared w the general individual

Answer 7

Risk of KS 20,000 times that of the general population,

300 times that of other immunosuppressed individuals

Question 8

Skin lesions.

Answer 8

most often starts as an ecchymotic-like macule
.Macules evolve into patches, papules, plaques, nodules, and tumors that
are violaceous, red, pink, or tan and become purple-brownish with a greening hemosiderin halo as they age. Often oval initially,and on the trunk enarranged parallel to skin tension lines . lesions may initially occur at sites of trauma, acral areas.

Question 9

Distribution

Answer 9

almost always occur on the feet and legs or the hands, and slowly spread centripetally.

In HIV/AIDS-associated KS,there is early involvement to the face and widespread distribution on the trunk

Question 10

Skin biopsy

Answer 10

Vascular channels lined by atypical endothelial cells among a network of reticulin fibers and extravasated erythrocytes with hemosiderin deposition.
In the nodular stage: Spindle cells in sheets and fascicles with mild- to-moderate cytologic atypia, single cell necrosis, trapped RBCs within an extensive network of slit like vascular spaces

Question 11

Confirmation of dx is done by?

Answer 11

lesional skin biopsy

Question 12

life span

Answer 12

CLASSIC KS Average survival,10to15years;
death usually from unrelated causes. Secondary malignancies arise in > 35% of cases.

AFRICAN-ENDEMIC KS Mean survival in young adults, 5 to 8 years; young children, 2 to
3 years.

Question 13

tx

Answer 13

RADIOTHERAPY Indicated or tumorous lesions, conf uent lesions with a large sur ace area, large lesions on distal extremity, and large oropha- ryngeallesions.Cryosurgery.Indicated or deeply pigmented, protruding nodules. Laser Surgery. Pulsed-dye laser e ective or small super cial lesions. Photodynamic T erapy. For small super cial lesions.
ELECTROSURGERY E ective or ulcerated, bleeding nodular lesions. Excisional Surgery. E ective or selected small lesions. Intral- esional Cytotoxic Chemotherapy. Vinblastine, Vincristine,andBleomycin.
Aggressive Intervention
Single-Agent Chemotherapy. With adria- mycin, vinblastine, lipid ormulations o daunorubicin and doxorubicin. Paclitaxel
( axol), thalidomide, and col-3. Combination Chemotherapy. Vincristine + bleomycin + adriamycin or inter eron-α + zidovudine