EPTIFIBATIDE (Integrilin) Flashcards
EPTIFIBATIDE (Integrilin)
Name/Class: EPTIFIBATIDE (Integrilin) Glycoprotein IIb/IIIa inhibitor, platelet aggregation inhibitor
Description: Prevents the aggregation of platelets by binding to the glycoprotein IIb/IIIa receptor, preventing the binding of fibrinogen and von Willebrand factors.
Indications: Unstable angina and NSTEMI (ACS) being managed medically.
Contraindications: Any prior intracranial hemorrhage, known malignant intracranial neoplasm, suspected aortic dissection, significant closed head trauma or facial trauma within 3 hours.
Precautions/Side Effects: Cerebral hemorrhage, pulmonary hemorrhage, hypotension, GI bleeding, internal bleeding, anaphylactic shock.
Dosage/Route: Medical management 180 ug/kg IV bolus over 1-2 minutes, followed by a 2 ug/kg infusion for 72-96 hours.
