9/13 Connective Tissue - Brauer (Completed)

Question 1

What are the main cells of Connective Tissue? 4

Answer 1

HAM COF

Hematopoietic stem cells
Adipocytes
Mesenchymal cells (CT stem cells)

Chondrocytes
Osteoblasts
Fibroblasts (collagen and glycans)

Question 2

What type of fibers form the supportive CT mesh work? 5

Answer 2

Reticular Fibers

Question 3

What is the most common type of collagen? 5

Answer 3

Type I

Question 4

What causes Scurvy? 6

Answer 4

Lack of Vit. C - a cofactor involved in cross-linking collagen fibers

Question 5

What is the problem in Ehlers-Danlos Syndrome? 6

Answer 5

Abnormal collagen synthesis producing weak collagen fibers

Question 6

What kind of inheritance is seen in Marian’s Syndrome? 8

Answer 6

Autosomal Dominant

Question 7

What is the problem in Marfan’s Syndrome? 7

Answer 7

Mutation in Fibrillin-1 gene

Question 8

What are the life threatening cardiovascular anomalies seen in Marfan’s Syndrome? 7

Answer 8

Dissecting aneurysms

Mitral Prolapse

Question 9

What components will be found within proteoglycans? 8

Answer 9

Chondroitins

Heparans

Keratans

Question 10

What is the role of Hyaluronan or Hyaluronic acid? 8

Answer 10

Provide a backbone which proteoglycans can attach to

Question 11

What is the EC matrix of the umbilical cord referred to as? What is it the source of? 10

Answer 11

Warton’s Jelly

Mesenchymal stem cells

Question 12

What kind of potently do Adult mesenchymal cells have? 11

Answer 12

They’re multipotent stem cells

Question 13

What are examples of loose CT? 12

Answer 13

Areolar

Adipose

Reticular

Question 14

What are examples of dense CT? 12

Answer 14

Regular

Irregular

Elastic

Question 15

What is Areolar loose CT? 13

Answer 15

Low density tissue w/ both fixed and wandering cells

Question 16

What is reticular loose CT? Give an example. 13

Answer 16

Reticular fibers forming a supportive mesh framework that holds free cells

Ex. Bone Marrow

Question 17

Give an example of dense irregular CT? 13

Answer 17

Dermis of the skin

Question 18

Give an example of Dense regular CT? 13

Answer 18

Tendons connecting skeletal muscle to bone

Question 19

What are the fixed cells found in loose Areolar CT? 14

Answer 19

Fibroblasts

Adipocytes

Mesenchymal cells

Question 20

What are the wandering cells found with in loose areolar CT? 14

Answer 20

Macrophages

Mast Cells

Leukocytes/Lymphocytes

Plasma cells

Question 21

What are the function of loose CT? 15

Answer 21

Supports and bind other tissues

Holds body fluids

Defends against infection

Question 22

Where would you find loose CT? 15

Answer 22

Around BVs, muscles, and nerves

Makes up the lamina propria

Question 23

What do you not find a lot of in Adipose CT? 17

Answer 23

ECM

Question 24

Where would you find Reticular CT? 19

Answer 24

Liver

Bone Marrow

Lymph nodes

Spleen

Question 25

What is the principle cell type found in dense irregular CT? 20

Answer 25

Fibroblasts

Question 26

What characterizes dense irregular CT? 20

Answer 26

Interwoven collagen fibers running in a random pattern

Question 27

Where would we find Dense Irregular CT? 20

Answer 27

Dermis of skin Capsules surrounding internal organs Perichondrium/periosteum Fascia

Question 28

What characterizes Dense Regular CT? 21

Answer 28

Tightly packed, regular arrangement of collagen fibers

Question 29

Why do tendons (dense regular CT) take such a long time to heal? 21

Answer 29

Due to being poorly vascularized

Question 30

Where can we find Dense Regular CT? 21

Answer 30

Tendons Ligaments Aponeuroses Dense fascia, joint capsules

Question 31

Where would we find Elastic CT? 22

Answer 31

BV walls Bronchioles tubes Special ligaments (ligmentum nuchae)

Question 32

What is the main role of Fibroblasts? 23

Answer 32

To make and maintain cells of the ECM

Question 33

What cells do Fibroblasts produce? 23

Answer 33

Collagen Elastin Reticular Fibers Proteoglycans Glycoproteins