9 Opioids Flashcards Preview

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Flashcards in 9 Opioids Deck (22)
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1
Q

Compare nociception with pain

A

3

2
Q

Describe pathway of pain

A

4

3
Q

How is pain modulated centrally / peripherally?

A

6

4
Q

How is pain reduced peripherally?

A

8

5
Q

How is pain reduced centrally?

A

10

6
Q

Name 3 endogenous opioids and 3 R subtypes

What are opioid R/

A

12

GPCR

7
Q

Where is MOP R found and what is it’s Fx?

A

13

8
Q

How does opioid uncoupling decrease pain?

A

15

9
Q

What is the effect of arrestin on increasing pain?

Explain the mechanism

A

16

10
Q

What is the effect of suddenly removing an opioid?

A

18

11
Q

Explain the absorbtion, distribution, metabolsim, elimination of morphine

A

25

12
Q

MoA / action / side effects morphine

A

26

13
Q

Explain the absorbtion, distribution, metabolsim, elimination of fentanyl

A

27

14
Q

MoA / action / side effects fentanyl

A

28

15
Q

Explain the absorbtion, metabolsim, elimination of codine

A

29

16
Q

Explain the absorbtion, distribution, metabolsim, elimination of buprenorphine

A

31

17
Q

MoA / action / side effects buprenorphine

A

32

18
Q

Explain the absorbtion, distribution, metabolsim, elimination of naloxone

A

33

19
Q

MoA / action / side effects naloxone

A

34

20
Q

Most common cx of death in opioid overdose

A

36

21
Q

Considerations when prescribing opioids

A

37

22
Q

Opioid dose for pallative care

  • months to weeks
  • days to hours
A

40