9- Receptors Flashcards Preview

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Flashcards in 9- Receptors Deck (37):
1

C1 drugs

Illegal

2

C-II drugs

Morphine, methylphenidate

3

C-III drugs

Drugs like Tylenol #3, codeine mixtures

4

C-IV drugs

Benzodiazepines

5

C-V drugs

OTC

6

True receptors elicit a response when?

When bound by an agonist

7

What happens when a drug binds to a nonregulatory molecules

There is no response

8

Covalent >Ionic> Hydrogen> hydrophobic> Van der Waals

Bond strength from strongest to weakest

9

Weak bonds have more selective or less selective binding?

More selective binding

10

Strong bonds will bind to receptor tightly or loosely?

What effect will this have?

Very tightly

Longer lasting effects

11

Why is drug shape important

Proper binding with receptor

12

Look at slide 11-13

Chirality

13

What are the ligand gated ion channels?

Nicotinic ACh

Glutamate

GABA

14

Where are nicotinic ACh receptors found?

Neuromuscular junction
Autonomic ganglia
CNS

15

What opens the nicotinic ACh receptors

Binding of 2 ACh molecules

16

Glutamate receptor agonists include...

AMPA
Kainite
NMDA

17

Glutamate is a major excitatory or inhibitory NT

Excitatory

18

GABA is a major excitatory or inhibitory NT

Inhibitory

19

GABA receptors are used by what kinds of drugs

Anxiety and sleep disorders

20

Voltage gated channels open due to what

Changes in membrane potentials

21

T/F voltage gated ion channels are opened by NT

False

22

Where are voltage gated ion channels found

In excitable tissues

23

Gs does what?

Activates adenylyl cyclase
Increase cAMP

24

Gi does this

Inhibits adenylyl cyclase

Decreased cAMP

25

Gq does what

Actives phospholipase C
Makes IP3 and DAG

26

Gs coupled receptors include.... (2)

B adrenergic (B1,2,3)
D1

27

Gi receptors include... (3)

M2, D2, A2

28

Gq receptors include... (3)

A1, M3, M1

29

What are growth factor receptors (tyrosine kinases)

Insulin
EGF
PDGF
HGF

30

What are cytokines receptors?

GH, erythropoietin, interferons

31

T/F receptor tyrosine kinases have an intracellular intrinsic kinase activity

True

32

Do cytokine receptors have an intrinsic factor?

No, they are mediated by JAK
JAK activates STAT

33

What is so special about steroid hormones

They are lipophillic, meaning they can pass right through the plasma membrane

34

Nitric Oxide readily crosses the membrane and reacts with what molecule?

Guanylyl cyclase

35

What are some examples of steroid hormones?

Corticosteroids, mineralocorticoids, sex steroids, thyroid hormone, vit D

36

What does NO stimulate

CGMP formation and downstream signaling

37

What are some 2nd messenger systems

CAMP
CGMO
IP3
DAG