Flashcards in 9- Receptors Deck (37):
Drugs like Tylenol #3, codeine mixtures
True receptors elicit a response when?
When bound by an agonist
What happens when a drug binds to a nonregulatory molecules
There is no response
Covalent >Ionic> Hydrogen> hydrophobic> Van der Waals
Bond strength from strongest to weakest
Weak bonds have more selective or less selective binding?
More selective binding
Strong bonds will bind to receptor tightly or loosely?
What effect will this have?
Longer lasting effects
Why is drug shape important
Proper binding with receptor
Look at slide 11-13
What are the ligand gated ion channels?
Where are nicotinic ACh receptors found?
What opens the nicotinic ACh receptors
Binding of 2 ACh molecules
Glutamate receptor agonists include...
Glutamate is a major excitatory or inhibitory NT
GABA is a major excitatory or inhibitory NT
GABA receptors are used by what kinds of drugs
Anxiety and sleep disorders
Voltage gated channels open due to what
Changes in membrane potentials
T/F voltage gated ion channels are opened by NT
Where are voltage gated ion channels found
In excitable tissues
Gs does what?
Activates adenylyl cyclase
Gi does this
Inhibits adenylyl cyclase
Gq does what
Actives phospholipase C
Makes IP3 and DAG
Gs coupled receptors include.... (2)
B adrenergic (B1,2,3)
Gi receptors include... (3)
M2, D2, A2
Gq receptors include... (3)
A1, M3, M1
What are growth factor receptors (tyrosine kinases)
What are cytokines receptors?
GH, erythropoietin, interferons
T/F receptor tyrosine kinases have an intracellular intrinsic kinase activity
Do cytokine receptors have an intrinsic factor?
No, they are mediated by JAK
JAK activates STAT
What is so special about steroid hormones
They are lipophillic, meaning they can pass right through the plasma membrane
Nitric Oxide readily crosses the membrane and reacts with what molecule?
What are some examples of steroid hormones?
Corticosteroids, mineralocorticoids, sex steroids, thyroid hormone, vit D
What does NO stimulate
CGMP formation and downstream signaling