9. UTI & Prostatitis MT2 Flashcards

(51 cards)

1
Q

does this describe a bladder infection or kidney infection?
cystitis, or lower UTI

A

bladder infection

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2
Q

does this describe a bladder infection or kidney infection?
pylonephritis, or upper UTI

A

kidney infection

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3
Q

this is the presence of significant amounts of bacteria in the urine without accompanying signs/symptoms of infection

A

asymptomatic bacteriuria

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4
Q

this is a lower tract disease (cystitis) that presents with dysuria, frequency, urgency and suprapubic tenderness

A

uncomplicated UTI

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5
Q

this is a metabolic, functional or structural abnormality and may involve both lower and upper tracts. has increased rate of treatment failure. males. systemic symptoms may include fever, increased leukocytes and decreased BP

A

complicated UTI

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6
Q

this is a UTI occurring in patients who are currently catheterized or have been catheterized within the previous 48 hours

A

CAUTI

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7
Q

this is inflammation of the renal parenchyma, calcies, and pelvis particularly due to local bacterial infection

A

pyelonephritis

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8
Q

this is sepsis resulting from the infection of extravasated urine or obstruction of infected urine

A

urosepsis

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9
Q

this is one of the oldest practices in medicine; it detects abnormalities of multiple diseases. includes multiple tests such as specific gravity, pH, protein, glucose, ketones, bilirubin, occult blood, leukocytes esterase, nitrate, urobilinogen, WBCs, RBCs, casts and bacteria

A

urinalysis

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10
Q

what is a urinalysis ‘technique’ to get a sample that is not contaminated

A

midstream catch - let some urine go and then get sample as the initial urine can contaminate the sample

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11
Q

what is seen in urinalysis for a UTI

A
  • bacteriuria (bacteria in urine)
  • hematuria (blood in urine)
  • nitrites (presence of bacteria that convert nitrate to nitrite e.g. E.coli)
  • pyuria (WBC’s in urine - may indicate inflammation including infection)
  • WBC casts (indicate renal origin of leukocytes)
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12
Q

what do gram stains tell us regarding UTIs

A
  • WBCs indicate whether or not there is an infection
  • epithelial cells indicate whether or not the sample is contaminated
  • tell us if for e.g. gram positive cocci, gram negative bacilli
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13
Q

what does culture & susceptibility test tell use regarding UTIs

A
  • what bacteria are on the growth media
  • biochemical tests are used for indentification
  • what antibiotics bugs are susceptible to
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14
Q

these are members of the normal intestinal flora of humans and animals and may be isolated from a variety of environmental sources (e.g. E.coli, Klebsiella, Enterobacter, Serratia, Citrobacter); all are gram-negative bacilli

A

Coliforms

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15
Q

this is a larger group of gram-negative bacilli; includes: coliforms, proteus, salmonella, Morganella, etc.

A

enterobacteriaceae

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16
Q

a positive coagulase test differents S. aureus from this group. they are part of the normal flora of the skin. have a relatively low virulence but are often resistant to common antibiotics. includes S. epidermidis, S. saprophyticus and S. hemolyticus

A

coagulase negative staphylococcus

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17
Q

true or false: fever, tachycardia and hypotension are seen in cystitis

A

false

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18
Q

true of false: increased peripheral blood WBCs in cystitis

A

false

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19
Q

true or false: WBC casts are present in cystitis

A

false

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20
Q

when are the only times asymptomatic bacteriuria should be treated

A
  • pregnancy
  • before transurethral resection of the prostate (TURP procedure) and urological procedures where mucosal bleeding is anticipated
  • bacteriuria persisting > 48 hours after catheter removal
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21
Q

what bacteria causes asymptotic bacteriuria

A

aerobic gram negative bacilli

22
Q

what is used for treatment of asymptomatic bacteriuria

A

TMP/SMX DS P.O x 3 days

23
Q

what bacteria causes asymptomatic bacteriuria in pregnancy

A

aerobic gram negative bacilli & coagulase-negative staph

24
Q

what is used for treatment of asymptomatic bacteriuria in pregnancy

A

amoxicillin, clay, cephalexin, fosfomycin (depending on trimester nitrofurantoin or TMP/SMX) x 3-7 days

25
what are the common pathogens of uncomplicated cystitis
- e.coli (and other enterobacteriae) - coagulate neg staph (saprophyticus) - enterococcus
26
what is the first line treatment for uncomplicated cystitis
nitrofurantoin PO x 5 days fosfomycin PO x 1 dose second line: TMP/SMX DS or ciprofloxacin PO x 3 days
27
what is the treatment for uncomplicated cystitis in pregnancy
fosfomycin PO x 1 dose cefixime PO x 7 days *avoid TMP/SMX in 1st and 3rd trimester *avoid Nitrofurantoin in 3rd semester *DO NOT use ciprofloxacin
28
what defines the need for prophylaxis treatment on recurrent uncomplicated cystitis
3 or more episodes per year
29
what is the treatment for prophylaxis of recurrent UTIs related to coitus
TMP/SMX or Nitrofurantoin PO pericoitus
30
what is the treatment for prophylaxis of recurrent UTIs not related to coitus
TMP/SMX PO hs or 3x/week or Trimethoprim PO hs x 6 weeks
31
what are the common pathogens of complicated UTI
- e.coli and other enterbacteriae - enterococcus spp - s. agalactiae - pseudomonas - corynebacterium urealyticum - aerococcus urinae
32
what is used for the treatment of a complicated UTI in a patient who is afebrile/systemically well
- amoxicillin/clav PO - cefixime PO - cipro PO - TMP/SMX PO
33
what is used for treatment of a complicated UTI in a patient who is febrile/systemically unwell
- Ampicillin + Gentamicin IV - ceftriaxone IV
34
what is used for treatment for a complicated UTI in a patient who is septic or hemodynamically stable
- pip/tazo IV +/- gentamicin IV (consider adding gentamicin if septic, recent abx use or history of MDR organisms)
35
is there a culture in urine, blood or both in pyelonephritis
both!
36
what are the usual pathogens in pyelonephritis
- E. coli and other enterobacter spp - enterococcus spp
37
what is the treatment for uncomplicated/moderately ill pyelonephritis
- amoxicillin/clav PO x 14 days - cipro PO x 7 days - TMP/SMX PO x 14 days
38
what is the treatment for hospitalized pyelonephritis
- Ampicillin + Gentamicin IV x 14 days - Ceftriaxone IV x 14 days - Cipro IV x 14 days - Tazocin IV x 14 days
39
what is the treatment for pyelonephritis in pregnancy
- Ampicillin + Gentamicin IV x 14 days - Ceftriaxone IV x 14 days
40
true or false: step-down from IV to PO can occur for treatment of pyelonephritis
true: based on culture & susceptibility test and whether pt can tolerate oral med
41
what is an important pharmacokinetic consideration (think ADME) for drugs used to treat both lower and upper urinary tract infections
Use renally cleared drugs - need to reach the site of infection!!!
42
this is known as inflammation of the prostate. most men present with discomfort or pain in the pelvic region for at least 3 months may be caused by reflux from the urethra or depletion of prostatic antibacterial factor symptoms: fever, chills, dysuria, frequency, bladder outlet obstruction, prostate tenderness, myalgia, recurrent UTI
prostatits
43
this is a prostatitis syndrome; severe symptoms, systemic infection, acute bacterial UTI
acute bacterial prostatitis
44
this is a prostatitis syndrome; chronic bacterial infection of the prostate +/- signs/symptoms of prostatitis. usually in setting of recurrent UTI (same strain)
chronic bacterial prostatits
45
this is a prostatitis syndrome; chronic pelvic pain +/- dysuria in absence of UTI. may be categorized as inflammatory or noninflammatory
chronic pelvic pain syndrome
46
this is a prostatitis syndrome; incidental finding of inflammation in absence of genitourinary tract symptoms
asymptomatic inflammatory
47
what are the common pathogens of prostatitis
most common is e. coli - klebsiella - proteus less common: pseudomonas, enterobacter, serratis, gram +ve organisms
48
how is prostatitis diagnosed
- prostate is tender and enlarged upon examination - STI ruled out - urine culture - blood culture
49
what is used for treatment of acute, mild/moderate prostatitis
- cipro PO - TMP/SMX for 2-4 weeks
50
what is used for treatment of acute severe prostatitis
pip/tazo IV for 2-4 weeks
51
what is used for treatment of chronic prostatitis
- cipro PO - TMP/SMX PO - Doxy PO for 4-6 weeks (may require up to 12 weeks)