Pharma-antihepa Flashcards
T/F
Goal for treating infections caused by HBV is to cure disease.
F
Suppress
T/F
Primary goal in HCV tx is Suppress the disease
F
Eradicate
Cytokine that acts by increasing activity of JAKS-> increasing formation of antiviral proteins
IFN-a
Also promotes NK cells formation
used for CHRONIC HBV
IFN-a
Lamivudine
____ IFN-a with____ offers better effectivity
oin CHRONIC HCV
Pegylated; Ribavirin
Competitively inhibits HBV DNA pol
Suppress HBV replication with improvement of liver histology and fibrosis
Adefovir
Toxicity that is dose limiting for adefovir
Nephrotoxicity
Ribavirin effective against
RIPHH(ab)irin
R Influenza A and B Paramxyxo HCV HIV
Lamivudine has longer intracellular half life with HBV infected cells than _____ infected Cells
HIV
thus lower dose for hepa than for HIV infection
T/F
Lamivudine can be used as a monotherapy
True.
With rapid suppression of HBVreplication and non toxic
For Chronic HCV with compensated liver disease
Ribavirin + IFN-a
T/F
Monotherapy with Ribavirin is effective
F
Early IV administration of this drug reduces mortality in VIRAL HEMORRHAGIC FEVERS
Ribaviring
Active against Lamivudine and Entecavir resistant strains
Tenofovir
Inhibits RNA Pol in HCV
Sofosbuvir
