Adrenergic Drugs, Etc.

Question 1

Alpha agonists and their receptors

Answer 1

Phenylephrine - a1

Clonidine - a2

Question 2

Mixed alpha and beta agonists and their receptors

Answer 2

Epi - a1, a2, b1, b2

NE - a1, a2, b1

Question 3

Beta agonists and their receptors

Answer 3

Dobutamine - b1
Isoproterenol - b1, b2
Albuterol - b2

Question 4

MOA of cocaine

Answer 4

Inhibit re-uptake of NE and DA

Question 5

MOA of Selegine and Phenelzine

Answer 5

Inhibit MAO

Question 6

MOA of amphetamine, methylphenidate and tyramine

Answer 6

Increase release of NE and DA

Question 7

Non-selective alpha (a1 and a2) receptor antagonists

Answer 7

Phentolamine

Phenoxybenzamine

Question 8

Selective a1 receptor antagonists

Answer 8

Prazosin
Tamsulosin
Doxazosin

Question 9

Mixed blockers and their receptors

Answer 9

Labetalol - b-, a1

Carvedilol - b-, a1

Question 10

b1 and b2 blockers

Answer 10

Propanolol
Pindolol
Nadolol

Question 11

b1 selective blockers

Answer 11

Metoprolol
Betaxolol
Acebutolol
Atenolol

Question 12

Phentolamine

Phenoxybenzamine

Answer 12

Non-selective alpha (a1 and a2) receptor antagonists

Question 13

Prazosin
Tamsulosin
Doxazosin

Answer 13

Selective a1 receptor antagonists

Question 14

Labetalol

Carvedilol

Answer 14

Mixed blockers and their receptors

Question 15

Propanolol
Pindolol
Nadolol

Answer 15

b1 and b2 blockers

Question 16

Metoprolol
Betaxolol
Acebutolol
Atenolol

Answer 16

b1 selective blockers

Question 17

NE release inhibitor

Answer 17

Guanethidine

Question 18

Inhibitor of tyrosine hydroxylase

Answer 18

Metyrosine

Question 19

Phenylephrine

Answer 19

Mydriatic and decongestant
Causes severe VC, increased BP, severe bradycardia
+a1

Question 20

Clonidine causes:

Answer 20

A decrease SNS outflow, lower BP and bradycardia

Question 21

What happens locally when clonidine is applied?

Answer 21

VC.

Question 22

How does clonidine decrease BP when it binds to an a2?

Answer 22

It is selective to a2 neurons in the brainstem and causes inhibition of NE release, which lowers BP and causes bradycardia.

Question 23

Isoproterenol

Answer 23

+ inotropic and chronotropic effect (b1)
VD (b2)
Bronchodilation (b2)

Question 24

What drug has unique activity at a1 receptors?

What is unique?

Answer 24

Dobutamine.

(-) isomer is an a1 agonist, while (+) isomer is an antagonist

Question 25

Dobutamine

Answer 25

Positive inotropic effect

Question 26

DA

Answer 26

VD (D1)
Suppression of NE release (D2)

At high doses, it activates b1 in heart.
At even higher doses, it activates vascular a1 and causes VC.

Question 27

What are the kinetics of phentolamine?

Answer 27

Reversible competitive alpha antagonist.

Shorter-acting.

Question 28

What are the kinetics of phenoxybenzamine?

Answer 28

Non-competitive alpha antagonist.

Long-acting.

Question 29

Beta-blockers’ effect on:

• Heart
• BVs
• RAAS
• Respiratory system
• Eye
• Metabolism

Answer 29

Heart: neg. inotropy/chronotropy, slow AV conduction.

BVs: initially, rise in PVR. Chronically, decrease in PVR.

RAAS: inhibit renin release.

Respiratory system: increased airway resistance.

Eye: dec. aqueous humor production and intraocular pressure.

Metabolism: inhibit lipolysis, increase LDL, inhibit sugar breakdown in liver.