RATE-LIMITING STEPS

Question 1

rate liming step of Lipogenesis

Answer 1

Acetyl CoA + HCO 3 – + ATP → Malonyl CoA

Enzyme: Acetyl CoA carboxylase​

Question 2

Rate limiting enzyme for PURINE SYNTHESIS

Answer 2

• PRPP glutamyl amidotransferase

Question 3

Which step is rate-limiting in TCA cycle?

Answer 3

Isocitrate → α-ketoglutarate

Enzyme: Isocitrate dehydrogenase

Question 4

rate limiting step of KETOGENESIS

Answer 4

Acetoacetyl CoA + Acetyl CoA → HMG CoA

Enzyme: HMG CoA Synthase​

Question 5

Rate limiting step of BETA-OXIDATION or LIPOLYSIS.

Answer 5

Translocation of fatty acyl CoA from the cytosol to the mitochondria

Enyzme: Carnitine-palmitoyl transferase​

Question 6

Which step is rate-limiting in PPP?

Answer 6

Glucose-6-phosphate → 6-phosphogluconate

Enzyme: Glucose-6-phosphate dehydrogenase (G6PD)

Question 7

Rate limiting step for Cholesterol Synthesis

Answer 7

Hydroxymethylglutaryl-CoA (HMG CoA) → Mevalonate

Enzyme: HMG-CoA Reductase Requirement: 2 NADPH​

Question 8

Which step is rate-limiting step of glycolysis?

Answer 8

Fructose-6-phosphate → Fructose-1,6-bisphosphate

Enzyme: Phosphofructokinase-1

Question 9

What is the rate-limiting step of Glycogenesis?

Answer 9

Elongation of glycogen chains i.e., creation of α-(1,4) glycosidic bonds Enzyme: Glycogen synthase

Question 10

What is the rate limiting step in Gluconeogenesis?

Answer 10

Fructose 1,6-bisphosphate → Fructose 6-phosphate

Enzyme: Fructose 1,6-bisphosphatase

Question 11

Rate-limiting step of UREA CYCLE

Answer 11

NH 3 + CO 2 → Carbamoyl phosphate

Enzyme: Carbamoyl phosphate synthetase I

Allosteric Activator: N-acetylglutamate