Molecular Mimicry & Autoinflammatory Disorders

Question 1

What is another name for streptococcus pyogenes (GABHS)?

Answer 1

Group A Streptococcus

Question 2

What are examples of disorders caused by molecular mimicry autoimmunity?

Answer 2

1. Acute Rheumatic Fever

2. Guillain Barre Syndrome

Question 3

What bacteria causes Acute Rheumatic Fever?

Answer 3

Streptococcus pyogenes (Group A strep)

Question 4

Describe Acute Rheumatic Fever

Answer 4

Usually occurs 2-3 weeks after GABHS pharyngitis. It develops as a result of cross-reactive antibody leading to inflammation of the heart, joints, brain, and vascular tissues.

Symptoms vary but common ones include aschoff body (heart nodules), fever, carditis, and arthritis.

Question 5

Describe Guillain Barre Syndrome

Answer 5

Follows after campylobacter infection. Due to damage of PNS.
Symptoms: muscle weakness

Question 6

What are examples of AUTOINFLAMMATORY diseases?

Answer 6

Periodic Fever Syndromes (usually resolves with age)

1. Familial Mediterranean Fever (FMF)
2. PFAPA (most common PFS in the US)