Erythrocyte Morphology/Nomenclature and Inclusion

Question 1

2-10 pointed projections of various lengths and irregular spacing; intensely stained

Answer 1

Acanthocyte

Spur cells

Question 2

Alcohol intoxication (Zieve’s syndrome)
Pyruvate kinase deficiency 
Abetalipoproteinemia, congenital
Vitamin E deficiency
Post splenectomy

Answer 2

Acanthocytes
Spur cells

2-10 intensely stained projections

Question 3

Contains one or more vacuoles that resemble a blister on the skin

Answer 3

Blister Cell

Question 4

10-30 pointed projected EVENLY DISTRIBUTED around the cell

Answer 4

Burr Cell
Echinocyte
Crenated RBC

Question 5

Post splenectomy patients
with enzyme anomalies
Artificial drying

Answer 5

Burr cells
Echinocytes
Crenated RBC

Question 6

Narrow and elongated

Resembling a rod or cigar shape

Answer 6

Elliptocyte

Pencil Cell

Question 7

Iron Deficiency Anemia
Hereditary elliptocytosis
Idiopathic myelofibrosis

Answer 7

Elliptocyte

Pencil cell

Question 8

Fragment in which the volume is close to normal

Answer 8

Keratocyte
Horned cell
Helmet cell

Question 9

G6PD deficiency

Pulmonary emboli

Answer 9

Keratocyte
Horned cell
Helmet cell

Question 10

Narrow band of hemoglobin across the center of the cell

Answer 10

Knizocyte

Pinch bottle cell

Question 11

Oval or egg-like in appearance

Answer 11

Ovalocyte

Elliptocyte

Question 12

Myelodysplastic syndromes
Thalassemia syndromes
Megaloblastic process

Answer 12

Ovalocyte

Elliptocyte

Question 13

Fragment in which cellular volume is reduced

Answer 13

Schistocyte

Schizocyte

Question 14

Prosthetic heart valves
Microangiopathic hemolytic anemia (DIC, TTP, HUS)
Clostridial infection

Answer 14

Schistocyte

Schizocyte

Question 15

Crescent shaped with at least one end that is pointed

Answer 15

Sickle cell

Drepanocyte

Question 16

Sickle Cell Anemia

Hemoglobin C harlem

Answer 16

Sickle cell

Drepanocyte

Question 17

Any cell with projections

Answer 17

Spiculated RBCs

Question 18

Myelofibrosis
Uremia
Post-splenectomy states

Answer 18

Spiculated RBCs

Question 19

Compact and round; has lost its area of central pallor and stains intensely

Answer 19

Spherocyte

Question 20

Immune hemolytic anemias
Hereditay spherocytosis
Post-transfusion
Possible pathology

Answer 20

Spherocyte

Question 21

Central slit-like opening resembling a mount

Answer 21

Stomatocyte

Question 22

Stomatocytosis

Answer 22

Stomatocyte

Question 23

Contains central bull’s eye surrounded by a clear ring and then an outer red ring

Answer 23

Target cell

Codocyte

Question 24

Hemoglobin C disease
Hemoglobin C Trait
Post-splenectomy
Liver disease
IDA
Thalassemua
Hemoglobin SC
LCAT DEFICIENCY

Answer 24

Target cell

Codocyte

Question 25

Resembles a tear

Has one elongated end

Answer 25

Teardrop cell

Dacrocyte

Question 26

Myelofibrosis

Answer 26

Teardrop cell

Dacrocyte

Question 27

Single, occasionally double, rarely multiple
Red purple coccoid bodies, 1-2 um in diameter

DNA: nuclear or chromosomal remnant

Seen in Megaloblastic anemia
Hyposplenism

Answer 27

Howell-Jolly body

Question 28

Clusters of small blue coccoid bodies located at the periphery of the cell

Non-heme iron

Seen in sideroblastic anemia
Hemolytic anemia

Answer 28

Pappenheimer body

Question 29

Multiple, uniform, dark dots
distributed evenly throughout the cell

Altered RNA

Seen in lead or heavy metal intoxication after treatment for iron deficiency or megaloblastic anemia

Answer 29

Basophilic stippling

Question 30

Red-purple ring at the periphery of the cell
May be in the form of a figure 8

Mitotic spindle remnant

Hyposplenism anemia

Answer 30

Cabot ring

Question 31

Invisible

Denatured, precipitated hemoglobin

G6PD Deficiency Hb which other hemolytic anemia

Answer 31

Heinz-Ehrlich body