L11 - Growth cones

Question 1

Lamella - actin structure

Answer 1

bundles crosslinked into net

Question 2

Filopodia - actin structure

Answer 2

large polarised bundles

Question 3

resting growth cone filopodia

Answer 3

F-actin treadmills, tubulin performs microtubule capture

Question 4

F-actin accumulation effect

Answer 4

stabilises filopodium, microtubule capture.

Question 5

What drives growth cone forward movement

Answer 5

stimulus - cytoskeletsl rearrangement

attachment to substrste

Question 6

Components leading to filopodia extension and microtubule reorientation

Answer 6

molecular clutch, actomyosin-based actin tubulin link

Question 7

Uncrosslinked f-actin chracteristic

Answer 7

little strength, no net movement = treadmilling

Question 8

Destabilised F-actin

Answer 8

growth cone collapse

Question 9

Rho GTPases

Answer 9

molecular switches that respond to extracellular signals

Question 10

GEFs

Answer 10

switches Rho GTPase ON

Question 11

Rho GTPases

Answer 11

control formation of actin based structures

Question 12

Activated Rac and cdc42

Answer 12

positive regulators of axon growth

Question 13

Activated RhoA

Answer 13

negative regulator of axon growth

Question 14

Growth requires

Answer 14

assembly and disassembly of actin structures

Question 15

Semaphorin signalling

Answer 15

alters RhoA/RAC balance

Question 16

Growth cone extension or collapse defined by

Answer 16

Rho/Rac balance

Question 17

How does calcium fluxes turn growth cones

Answer 17

calcium regulates Rho GTPases

Question 18

Growth cone behaviour control -

Answer 18

interactions between pathways controlling the actin cytoskeleton and microtubules