L10 - Neuronal Polarity Flashcards by Isabella Smyth

Q

True or false - neurons have polarity

A

true

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Q

Dendrite function

A

integrate incoming information

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Q

Axon structure

A

highly polarised microtubules

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Q

Dendrite microtubules

A

less ordered, mixed orientations

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Q

MAPs (microtubule associated proteins) function

A

stabilise microtubules through cross-linking

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Q

Plasma membrane =

A

compartmentalised

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Q

Membrane compartments maintained by

A

actin dependent diffusion barriers

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Q

Axon microtubules

A

minus ends towards cell bodies

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Q

GFP labelled plus end directed kinesins mark

A

where axons try to form

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Q

neurite choice

A

stochastic, feedback loop , competition

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Q

Factors underlying axon choice

A

tyrosinated or acetylated microtubules ????

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Q

Acetylated microtubules

A

stabilised, present in newly polarised axons

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Q

Growth cones and neurite microtubules

A

tyrosinated dynamic microtubules

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Q

Activator function in positive feedback loop

A

amplifies signal

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Q

Likely feedback loop

A

HRas & PI3K positive loop

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Q

HRas depletion

Study These Flashcards

A

non-axonal regions.

Q

Phosphorylated AKt location

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A

nascent axons

Q

GSK3b inhibits

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A

microtubule stabilisation

Q

Effect of inhibiting GSK3b

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A

neurons with multiple axons

Q

Neuronal polarity affected by

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A

proteins involved in asymmetric division EG Par

Q

PAr3 complex localisation

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A

nascent growth cones

Q

PIP3 inhibition

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A

prevents PAR3 accumulation and axon formation

Q

Balance between PAR related kinases promotes

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A

axonogenesis

Q

Axon initiation in vivo requires

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A

LKB1

MAP2 marks

dendrites

Tau marks

axons

Semaphorins

inhibitory guidance cue family

Sema3 expression

gradient from basal to apical

Sema3 function

attracts dendrites basally, promotes dendrite formation

Polarity can be inherited and established

true