Rheumatic Heart Disease (Cardiac Diseases) Flashcards

1
Q

rheumatic heart disease (RHD)

A
  • part of rheumatic fever (RF)
  • must have RF to get RHD
  • mostly occurs in children
  • preceded by strep throat or genetic
  • molecular mimicry
  • systemic effects (Abs target Ags in heart, joints, CNS, integument)
  • infection in pharynx not heart
  • inflm of valves, myocardium, and pericardium
  • chronic RHD leads to severe heart damage
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2
Q

molecular mimicry in RHD

A
  • normally, child has strep throat, T cells and Abs form and an infection is eradicated by defense cells
  • however, if child pre-disposed to molecular mimicry, the child’s Abs that were created to eradicate strep throat will begin to attack self-Ags (occurs 1 week after infection)
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3
Q

acute form of RHD

A
  • self-limiting (heals on its own)

- continue to monitor and Tx as symptoms arise

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4
Q

Mnfts

A
  • general cold/cough
  • valvular dysFx (d/t inflm near chordae tendinae) r/t in:
  • SOBOE, weakness, fatigue, edema, chest pain
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5
Q

Dx

A
  • Dx strep throat first (throat swab), however, this infec may have cleared by time RHD symptoms arise
  • non-specific tests: CBC, ESR, CRP, Differential
  • Dx complex b/c no specific tests can be done & symptoms child has very general
  • no CKMB released b/c no necrosis of tissue
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6
Q

Tx

A
  • prompt Dx and Tx of strep throat
  • erythromycin and penicillin (Abx) + anti-inflammatories
  • BED REST key to recovery to dec workload
  • symptomatic management –> handle cardiac cmplx
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