Postmenopausal Hormone Replacement Therapy Flashcards
Why may HRT be prescribed?
- Symptoms
- Osteoporosis
- Heart disease
What menopausal symptoms could be allievated with HRT?
- Hot flushes/sweats
- Vaginal dryness/dyspareunia
What are the risks of unopposed oestrogen replacement therapy (ORT)?
Increased risk of developing endometrial and ovarian cancer s
What are the risks of hormone replacement therapy?
- Increased risk of stroke
- Increased risk of venous thromboembolism
What is the risk of opposed oestrogen therapy (HRT)?
Increased risk of developing breast cancer
What effect does HRT have on the risk of ischaemic heart disease?
It reduces it
Why does HRT reduce the risk of ischaemic heart disease?
It has a beneficial effect on the lipid profile
What is the effect of HRT on the lipid profile?
- Increased HDL-C
- Decreased oxoLDL-C
- Decreased triglyceride
- Decreased lipoprotein
When is the effect of HRT on the lipid profile biggest?
If the patient is not already overweight
When does tibolone precipitate stroke?
>60 years of age
Why does HRT increase the risk of venous thromboembolism?
It has an adverse effect on the thromboembolism profile
What is the effect of HRT on the thromboembolism profile?
- Increased activated protein C resistance
- Increased thrombin activation
- Decreased anti-thrombin III activity
- Decreased protein S levels
- Decreased factor VII levels
- Decreased tissue factor pathway inhibitor
When does HRT have an adverse effect on the thromboembolism profile?
Oral delivery systems
What are the routes of administration for HRT?
- Oral
- Transdermal
- Implant
- Transvaginal
- Nasal
Is HRT effective for the prevention of heart disease?
No
