Drugs for Vasculitities and Goodpasture's

Question 1

The alkylating drug, cyclophosphamide is used for treatment of what?

Answer 1

malignant diseases

minimal change nephrotic syndrome (peds)

ANCA vasculities and Goodpasture’s

Question 2

What are the contraindications for Cyclophosphamide?

Answer 2

HSN reaction to the drug itself

urinary outflow obstruction

Question 3

What are the warnings of Cyclophosphamide?

Answer 3

immunosuppression

renal toxicity

cardiotoxicity

pulmonary toxicity

Veno-occlusive liver disease

embryo/fetal toxicity

Question 4

What are common side effects of cyclophosphamide?

Answer 4

neutropenia (febrile)

alopecia

fever

vomiting/diarrhea

Question 5

What are the indications for CD20 ab, Rituximab?

Answer 5

NHL

CLL

RA

ANCA vasculities and Goodpasture’s

Question 6

What are the contrainidications for Rituximab?

What is the black box warning?

Answer 6

None!

Fatal infusion reaction

TLS

severe mucocutaneous reactions

PML

Question 7

In cancer patient’s treated with Rituximab, what were the common side effects?

Answer 7

infusion reactions

fever

lymphopenia

neutropenia

Question 8

In RA patients treated with rituximab, what were the common side effects?

Answer 8

URI

nasopharyngitis

UTI

bronchitis

Question 9

What is the main toxicity when Rituximab is combined with Cisplatin?

Answer 9

Renal toxicity

Question 10

What are the indications for Azathioprine?

Answer 10

adjunct to prevent rejection in renal transplant

manage RA along with ASA/NSAIDs, or glucocorticoids

ANCA vasculities and goodpasture’s

Question 11

What are the contraindications for Azathioprine?

Answer 11

HSN to the drug

pregnancy (may increase risk for malignancy)

Question 12

What are the warnings associated with Azathioprine?

Answer 12

lymphoma and skin cancers (avoid sunlight)

*immunosupressive drug therapy should be maintained at the lowest effective levels

Question 13

What is a limitation in use for Cyclophosphamide?

Answer 13

the safety and efficacy for the treatment of nephrotic syndrome in adults or other renal disease has NOT been established

Question 14

What are the two types of ANCA assays in wide use?

Answer 14

• indirect immunofluorescence assay using alcohol buffy coat leukocytes
• ELISA using purified specific antigens

Question 15

What are some drugs that may induced vasculities?

Answer 15

hydralazine

propylthiouracil

methimazole

carbimazole

minocycline