Unit 1.2.c.iii

Question 1

What does the addition or removal of phosphate cause? What is this a common form of?

Answer 1

Reversible conformational change in proteins

Post-translational modification

Question 2

What protein catalyses the transfer of a phosphate group to other proteins

Answer 2

Kinases

Question 3

What protein catalyses the reverse reaction of phosphorylation

Answer 3

Phosphatase

Question 4

What does phosphorylation bring?

Answer 4

Conformational changes which can affect a protein’s activity

Question 5

What happens to different proteins when phosphorylation occurs?

Answer 5

Activated or inhibited

Question 6

Adding a phosphate group adds (1). (2) in the unphosphorylated protein can be disrupted and new ones created

Answer 6

1. Negative charges

2. Ionic interactions