Lecture 5

Question 1

What are the two types of innate response?

Answer 1

immediate and induced response

Question 2

What complement do all 3 complement system lead to?

Answer 2

C3

Question 3

Describe C3 fixation.

Answer 3

C3 is cleaved to create C3b which binds to bacterium and C3a which recruits phagocytosis

Question 4

Describe the process of opsonization in C3B.

Answer 4

C3b binds to CR1 receptors on macrophage triggering endocytosis and destroying pathogens

Question 5

What is the function of C5b?

Answer 5

to initiate the formation of the membrane attack complex

Question 6

What are the main functions of anaphylatoxins?

Answer 6

to increase vascular permeability, to cause inflammation, and to speed up pathogen destruction

Question 7

What is a mast cell?

Answer 7

activated by anaphylatoxins to degranulate, hold granules of inflammatory mediators

Question 8

What is the rapid response of the immediate innate immune system due to?

Answer 8

complement circulation and macrophage availability