Immunotherapy and Disease

Question 1

cause of rheumatoid arthritis

Answer 1

immune cells infiltrate synovial fluid- produce inflammatory cytokines

Question 2

2 strains of EBOLA

Answer 2

zaire and sudan

Question 3

what does the ebola virus mainly effect?

Answer 3

monocytes/macrophages- leading to massive cytokine and interferon release (TNFa and IFNy)
Disruption of the architecture of vascular endothelium and tissues

Question 4

COVID19 structure

Answer 4

single strand RNA virus
~100 nm diameter
30,000 nucleotides
Spike structure

Question 5

what makes COVID 19 highly transmissible?

Answer 5

Mutations in contact residues of the SARS COVID spike protein appear to allow SARS to optimally bind to its receptor of cells, the human ACE2 receptor angiotensin converting enzyme 2

Question 6

characterization of COVID19 immune response

Answer 6

acute respiratory distress syndrome
increased IL6, IL8 TNFa and IP10 (chemokine) in serum
cytokine storm

Question 7

how do antivirals work?

Answer 7

by inhibiting the viruses ability to replicate

Such antiviral drugs have proven very effective at treating HIV/AIDS and Hep C