Glial Cell Biology ILO 1 - Identify key components of the central immune system

Question 1

<p>What are the 4 glial cell types?</p>

Answer 1

<p>Astrocytes, microglia, NG2 glia and oligodendrocytes</p>

Question 2

<p>Where do CNS resident macrophages reside?</p>

Answer 2

<p>Perivascular, subdural and meningeal compartments</p>

Question 3

<p>What is the relation between peripheral innate/adaptive immune cells and meningeal fibroblasts and the CNS?</p>

Answer 3

<p>Reside in the borders of the CNS and can be recruited from the circulation during injury
Meningeal fibroblasts can produce ECM after injury</p>

Question 4

<p>What are the 4 fluid compartments of the brain?</p>

Answer 4

<p>Lateral ventricle, choroid plexus, third ventricle, fourth ventricle</p>

Question 5

<p>What 5 cell types make up the blood brain barrier?</p>

Answer 5

<p>Endothelial cells, smooth muscle, astrocytes, pericytes, microglia</p>

Question 6

What is the role of the blood/CSF barrier?

Answer 6

Prevents the moment of unwanted molecules and pathogens between the blood and CSF

Question 7

What is the role of the glymphatic system?

Answer 7

Provides movement of nutrients and ions from arteries through astrocytes to veins.
Disruption -> disease

Question 8

How does glia:neuron ratio change with mammal complexity?

Answer 8

Glia:neuron ratio increases as mammals become more complex

Question 9

What are the origins of astrocytes, microglia and oligodendrocytes?

Answer 9

Astrocytes and oligodendrocytes are ectodermal in origin.
Astrocytes - dorsal neural stem cells
Oligodendrocytes - ventral neural stem cells

Microglia are mesodermal in origin. Derived from myeloid stem cells.