E.4 Chemistry of anti-platelet agents Flashcards
1
Q
True/False. Integrin receptors are sensory and occur on platelet and other blood cells such as white blood cells
A
True
2
Q
What are integrin receptors and what do they act as ?
A
They are membrane proteins acting as cell-cell and cell-matrix connectors
They are heterodimers with a alpha and beta subunits
Metal ion depend on ligand binding
Many ligand contain the tripeptide motif RGD
They undergo large conformational changes
They are more complex than other membrane proteins
3
Q
What are the main functions of integrin cell surface receptors
A
Multiple function Cellular growth/death Embryogenesis Almost as is Angiogenesis
