Breast Disease

Question 1

What are the 4 types of breast cancer?

Answer 1

1) Ductal carcinoma in situ (DCIS)
2) Invasive ductal carcinoma (IDC)
3) Lobular carcinoma in situ (LCIS)
4) Invasive lobular carcinoma (ILC)

Question 2

What are the features of DCIS?

Answer 2

• Non-invasive

- Premalignant

Question 3

What does DICS look like on mammogram?

Answer 3

Microcalcification

Question 4

What is the most common type of breast cancer?

Answer 4

Invasive ductal carcinoma (70% of breast cancers)

Question 5

What can some DCIS progress to?

Answer 5

IDC

Question 6

Describe the mass in IDC

Answer 6

Unilateral, firm mass

Question 7

How does IDC metastasise?

Answer 7

Through lymph or blood

Question 8

What does Paget’s disease of the breast look like?

Answer 8

Red/scaly lesion on the nipple - looks like eczema

Question 9

What happens in Paget’s disease of the breast?

Answer 9

• Cancerous cells in the ducts move through a pore and settle between the squamous epithelial cells on the nipple
• This resulting inflammation brings ECF out from the breast onto the skin, which then dries and crusts

Question 10

How do you diagnose Paget’s disease of the breast?

Answer 10

Biopsy

Question 11

What are the key features of LCIS?

Answer 11

• In lobules, doesn’t invade ducts
• Increases cancer risk in either breast
• Uncommon

Question 12

How do you diagnose LCIS?

Answer 12

Biopsy

Question 13

What type of breast cancer is typically ER+?

Answer 13

ILC

Question 14

What % of breast cancers are ILC?

Answer 14

10-15%

Question 15

What do ILCs typically progress from?

Answer 15

LCIS

Question 16

What are the key features of ILC?

Answer 16

• Bilateral + multifocal lesions (less palpable)

- Low E-cadherin expression

Question 17

How does ILC metastasise?

Answer 17

Abdominal viscera