AKI

Question 1

What is the NICE criteria for AKI?

Answer 1

Rise in creatinine >=25mm/L in 48 hours
Rise in creatinine >= 50% in 7 days
Urine output <0.5ml/Kg/hr for >6 hours

Question 2

What symptoms and signs may be present in AKI?

Answer 2

Reduced urine output
Pulmonary and peripheral oedema
Arrhythmias (due to changes in potassium and acid-base balance)
Features of uraemia (e.g. pericarditis or encephalopathy)

Question 3

Which medications have to be stopped in AKI?

Answer 3

Medications that worsen renal function:
NSAIDs (Except aspirin)
Aminoglycosides (e.g gentamicin)
ACE inhibitors
ARB
Diuretics

Medications that increase risk of toxicity in AKI:
Metformin
Lithium
Digoxin