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DERM > Development & Structure of Epidermis > Flashcards

Development & Structure of Epidermis Flashcards

1
Q

describe the formation of the epidermis

A

ectoderm layers form single layer periderm, gradual increase in number of cells, periderm cells cast off

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2
Q

what is the epidermis

A

the outer layer of skin, statified cellular epithelium

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3
Q

what is the dermis

A

layer beneath epidermis, contains connective tissue

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4
Q

describe what the dermis is formed from

A

formed from mesoderm below ectoderm

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5
Q

describe what is found at 4 weeks of foetal skin development

A

periderm, basal layer and dermis

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6
Q

describe what is found at 16 weeks of foetal skin development

A

keratin layer, granular layer, prickle cell layer, basal layer, dermis

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7
Q

what happens to melanocytes at 16 weeks of foetal skin development

A

they migrate from the neural crest

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8
Q

describe what Blaschko’s lines are

A

the development growth patterns of skin, not following nerves, blood vessels or lymphatics

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9
Q

what does skin consist of

A

epidermis, appendages, dermo-epidermal junction, dermis, sub-cutis

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10
Q

what type of epithelium is the epidermis and how thick it is

A

stratified squamous epithelium, 1.5mm thick

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11
Q

what are the 4 defined layers of the epidermis, from outer most to inner most layer

A

keratin layer, granular layer, prickle cell layer, basal layer

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12
Q

what different types of cells are found in the epidermis

A

keratinocytes(95%), melanocytes, Langerhans cells, Merkel cells

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13
Q

what is the epidermal turnover regulated by

A

growth factors, cell death and hormones

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14
Q

where do keratinocytes migrate from

A

the basement membrane

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15
Q

describe the features of the basal layer of the epidermis (4)

A

usually one cell thick, small cuboidal, lots of intermediate filaments, highly metabolically active

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16
Q

describe the features of the prickle cell layer of the epidermis (3)

A

larger polyhedral cells, lots of desmosomes(connections), intermediate filaments connect to desmosomes

17
Q

describe the features of the granular layer of the epidermis

A

large keratohyalin granules, odland(lamellar) bodies, high lipid content, origin of ‘cornified envelope’,

18
Q

how many layers of cells are found in the granular layer of the epidermis

A

2-3 layers of flatter cells

19
Q

describe the features of the keratin layer of the epidermis

A

corneocytes, insoluble cornified envelope, 80% keratin + filaggrin, lamellar granules release lipid, tight waterproof barrier

20
Q

describe what corneocytes are

A

overlapping non-nucleated cell remnants

DERM (17 decks)

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