Receptor classification Part 1 Flashcards
What is the structural difference between adrenaline and noradrenaline?
Adrenaline has an extra methyl group
What are the family of receptor proteins for noradrenaline and adrenaline?
Adrenoreceptors
The receptor in the blood vessel has a higher affinity for _______ and the receptor in the heart muscle has higher affinity for _________
Blood vessel - Noradrenaline (alpha adrenoceptor)
Heart muscle - Adrenaline (beta adrenoceptor)
What does the alpha receptor have a higher affinity for ?
Noradrenaline
What is the beta 1 selective antagonist adrenoceptor?
Atenolol
What type of adrenoceptor is salbutamol?
B2 selective agonist adrenoceptor
Where is there a high potency of B2 receptor?
In the airway
Give 3 examples of signal transduction mechanisms that the receptor protein could be attached to?
Ion flux
Enzyme activity
Gene expression
What are the 4 superfamilies?
- Ligand -gated ion channels
- G-protein-coupled receptors
- Kinase-linked receptors
- Nuclear receptors
Give examples of ligand-gated ion channels receptors.
Nicotonic
ACh receptor
What is the fastest superfamily ?
Ligand-gated ion channels
Give examples of G-protein-coupled receptors.
Muscarinic
ACh receptor
Give an example of kinase-linked receptor
Cytokine receptors
Give an example of nuclear receptors
Steroids/hormones - oestrogen receptors
How will families within the same superfamilies differ?
The binding site that the chemical mediator binds to
