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3b/4 > Dermatology > Flashcards

Dermatology Flashcards

1
Q

what are the life-threatening causes of rash?

7

A 
meningococcal septicaemia
anaphylaxis
necrotizing fasciitis 
TEN/SJS
urticaria - anaphylaxis
staph scalded skin syndrome
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2
Q

what disease and causative organisms cause superficial epidermal infection typically around childrens faces?

A

impetigo

staph 90%, strep pyogenes

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3
Q

which 2 presentations of cellulitis are you most worried about - need referral/senior help?

A

necrotizing fasciitis

orbital cellulitis

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4
Q

when pain experienced is disproportionate to rash and also presence of systemic involvement?

A

nec fasc

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5
Q

fever + non-blanching purpuric rash + arthralgia, malaise, headache, neck stiffness, photophobia - dx?

A

meningococcal septicaemia

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6
Q

tx for meningococcal septicaemia in hospital?

A

IV Ceftriaxone 4G STAT

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7
Q

likeliest pathogen in meningococcal septicaemia?

A

neisseria meningitidis

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8
Q

meningitis with a complication of adrenal failure is called??

A

Waterhouse-Friderichsen syndrome

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9
Q

flat lesions, initially evolving -> itchy scabs.

Macules+papules+vesicles+pustules+scabs - dx?

A

chickenpox

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10
Q

chickenpox has a centripetal distribution - what does this mean?

A

spreading outwards from trunk

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11
Q

chickenpox causative organism?

A

varicella-zoster virus

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12
Q

pain and blistering rash which does not cross the midline +/- malaise - dx?

A

shingles

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13
Q

multidermatomal shingles is indicative of ________?

A

immunocompromise

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14
Q

when will the infectious period of shingles/chickenpox begin and end?

A

48hours before the presence of the rash - until all lesions crust over (5-7 days after)

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15
Q

which organism causes shingles?

A

herpes zoster virus

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16
Q

tx of shingles and when to initiate?

A

valaciclovir 1G TDS for 7 days

start within 72h onset of rash

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17
Q

shingles type illness + face pain + external auditory canal vesicles + ipsilateral facial palsy is called?

A

Ray-Hunt syndrome

complete recovery in <50%

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18
Q

prodrome of fever, coryzal illness, cough then a rash from face/neck to trunk/limbs - dx?

A

measles

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19
Q

measles have pathognmonic spots called ____? what colour are these and where are they noticed?

A

Koplik spots
grey
buccal mucosa 2 days prior to rash

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20
Q

measles: what type of rash is seen?

A

maculopapular rash

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21
Q

rash WITH fever and coryzal symptoms (+arthralgia in adults)
discrete macular rash from face -> trunk/limbs - dx?

A

rubella

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22
Q

if get rubella in first trimester of pregnancy - what complications are expected?

A

90% foetal abnormalities

deafness and cataracts

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23
Q

prodrome viral illness -> rash +/- itch

widespread maculopapular rash - dx?

A

viral exanthema - the viral rash

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24
Q

disease course viral exanthema?

A

self-limiting resolves over 7days

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25
Q

non-itching rash on cheeks. Feels burning hot. Erythematous. Later moves to trunk and limbs - dx?

A

Fifth disease/Erythema Infectiosum (slapped cheek fever)

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26
Q

reticulate erythema means ???

A

net-like rash

on proximal limbs and trunk in fifth disease

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27
Q

organism causing Fifth disease/Erythema Infectiosum (slapped cheek fever)?

A

parvovirus b19

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28
Q

small, painful vesicles around mouth, genitals. vesicles or pastules - which dx?

A

herpes simplex virus

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29
Q

if rash around mouth - which organism ?

A

HSV1

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30
Q

If rash around genitals - which organism?

A

HSV2

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31
Q

tx of HSV?

A

if primary infection - aciclovir 200mg/5h PO

if flare-up - topical aciclovir 5% apply to affected area /4hrly

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32
Q

small, non-itchy spots on trunk and limbs (+groin in adults)

  • small translucent papules, appear fluid-filled, actually solid
  • central depression (punctum) - which dx?
A

Molluscum Contagiosum

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33
Q

which organism causes molluscum contagiosum?

A

poxvirus

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34
Q

tx of molluscum contagiosum?

A

usually none, if older/adult - potassium hydroxide 5%

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35
Q

what are dermatophytes?

A

pathogenic fungi causing a wide range of diseases

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36
Q

mild, itchy, asymmetrical rash which spreads with a slightly raised, scaly edge, often leaving a clear centre - dx?

A

tinea corporis (‘ringworm’)

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37
Q

dermatophyte infection of the face?

A

tinea faciei

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38
Q

ringworm type infection in the groin with lesion more red and plaque-like with a well demarcated border ?

A

tinea cruris

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39
Q

in webspacecs of toes, itchy skin which is fissured and macerated. if elsewhere on foot is often more diffuse and scaly but still as itchy. +/- pustules - dx?

A

athletes foot - tinea pedis

rx - topical imidazole then oral antifungal

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40
Q

dermatophyte infection treatment?

(trichophyton rubrum) onychomyocosis

A

topical antifungals like terbinafine, clotrimazole, miconazole..
more widespread infections: PO terbinafine, itraconazole

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41
Q

organism causing nappy rash, in body folds (intertrigo) and mimicking tinea pedis - interdigital webbed spaces?

A

candida albicans

yeast

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42
Q

erythematous rash, with a ragged peeling edge which may contain pustules.
commonly of mouth and GU tracts and presents with small white plaques/discharge - dx?

A

candida albicans

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43
Q

candida albicans tx?

A 
skin hygeine - clean and dry
topical antifungal - clotrimazole
nystatin drops (mouth)
clotrimazole pesseries (vag) 
persistent - PO fluconazole
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44
Q

intensely itchy rash, often worse at night

papular rash found in interdigital webspaces of the hands and feet, ankles, wrists, genitals, axillae, umbilicus - dx?

A

scabies

mite infection

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45
Q

linear skin burrows are pathognomonic of ?

A

scabies

type IV hypersensitivity reax

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46
Q

tx of scabies?

A

permethrin / malathion - whole body
tx close contacts.
wash all clothes and bedding. itch may persist 4wks
severe may require PO tx

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47
Q

scabies organism?

A

sarcoptes scabiei

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48
Q

blood sucking parasites found on head and skin - orgs?

A 
lice
pediculosis capitis (head)
pediculosis corporis (body - not GU)
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49
Q

pubic lice organism?

A

phthiriasis pubis or ‘crabs’

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50
Q

tx of lice?

A

malathion / permethrin (resistance common)

tx close contacts and clothing and bedding

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51
Q

6 different types of eczema?

A
  1. atopic
  2. contact
  3. venous stasis
  4. seborrheic
  5. dyshidrotic eczema
  6. Nummular eczema
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52
Q

what is the atopic triad?

A

asthma
eczema
hayfever
(food allergies too but not part of triad)

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53
Q

commonest sites of eczema?

A

skin creases, hands, elbows, backs of knees, face and scalp

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54
Q

what is meant by the itch-scratch cycle?

A

Scratching damages skin barrier, leading to worse Sx, leading to more scratching
disrupted sleep

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55
Q

what does lichenification indicate re eczema severity?

A

severe eczema

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56
Q

which organism is usually responsible for infected eczema?

A

saureus

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57
Q

tx of infected eczema (moderate and severe):

A

2 topical Abx = fusidic acid or mupirocin cream

Systemic Abx = Erythromycin or flucloxacillin (14 day course in severe)

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58
Q

5 examples of eczema triggers:

A 
irritants - detergents
env- cold dry weather
cows milk
wool irritating skin
hormonal changes - period
infections
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59
Q

managing itch in eczema:

8

A 
avoid triggers
rub/pinch/pat skin rather than scratch 
keep nails short
wear cotton gloves to sleep
keep skin covered with light clothing
moisturise frequently
cleansers with low pH
cold compress
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60
Q

tx of mild eczema:

A

emollients

mild topical corticosteroids

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61
Q

tx of moderate eczema:

A

emollients
moderate topical corticosteroids
topical calcineurin-inhibitors
bandages and dressings

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62
Q

tx of severe eczema:

A 
emollients 
potent topical corticosteroids
topical calcineurin-inhibitors 
bandages and dressings
PHOTOtx
systemic therapy
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63
Q

eg of mild corticosteroid for eczema?

A

hydrocortisone 0.1-2.5%

flucinolone acetonide .0025%

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64
Q

eg of very potent corticosteroid for eczema?

A

clobetasol propionate

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65
Q

eg of topical calcineurin inhibitors for eczema?

A

tacrolimus
pimercrolimus
(topical)

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66
Q

what is dishydrotic eczema also known as?

A

pompholyx

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67
Q

what is pompholyx commonly associated with?

A

hayfever

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68
Q

tx dishydrotic eczema?

A

soak hands and feet in cold water 15mins qds afterwards moisturise

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69
Q

‘Coin-shaped’ spots on the skin, itchy or not itchy, dry and scaly or wet and open, anywhere on the body - which type of eczema is this?

A

nummular

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70
Q

tx nummular eczema?

A

strong steroid cream

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71
Q

Skin will appear, red, itchy, greasy, swollen with white crusty flakes - which eczema?

A

seborrheic dermatitis

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72
Q

which drugs can exacerbate infections of psoriasis?

A

BBs

lithium

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73
Q

what is the dx if the lesions bleed when scratched?

A

psoriasis

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74
Q

which psoriasis occurs generalised and is an emergency?

A

pustulised

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75
Q

which psoriasis occurs 2-3 weeks post strep throat infection?

A

guttate psoriasis

rx - reassurance and topical tx if symptomatic

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76
Q

treatment of psoriasis:

A

topical emollients and steroids + vit D analogues (first line)
retinoid, coal tar, mtx, phototx

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77
Q

treatment of urticaria:

A

antihistamines

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78
Q

tender, erythematous nodules or plaques typically on the shins indicates:???

A

erythema nodosum - no tx - f/u

can also be forearms

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79
Q

commonest and other common causes of erythema nodosum?

A

strep commonest
mycoplasma pneumoniae, TB, EBV
sarcoid, IBD, AI disease, preg

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80
Q

target lesion indicates:

A

erythema multiforme

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81
Q

erythema multiforme major is when what additional feature present?

A

rash involvement of mucous membrane typically the mouth

can be ‘major’

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82
Q

which infection is indicated with erythema multiforme?

A

mycoplasma pneumoniae

HSV commonest cause

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83
Q

widespread blisters, with skin shredding, erythematous macules, mucosal erosions affecting <10% total body suerface area?

A

SJS

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84
Q

widespread blisters with skin shredding, erythematous macules, mucosal erosions affecting >10 (usually >30%) of the total body SA?

A

TEN

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85
Q

causes of TEN and SJS - infections -

A

HSV
mycoplasma pneumoniae
CMV
HIV

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86
Q

causes of SJS/TEN - drugs:

A

anti-epileptics
Abx - penicillins
Allopurinol
NSAIDS

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87
Q

tx SJS, TEN?

A

steroids, IVIGs, immunosuppression by specialists

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88
Q

The steroid ladder from weakest to most potent in eczema: 4

A

Mild: Hydrocortisone 0.5%, 1% and 2.5%
Moderate: Eumovate (clobetasone butyrate 0.05%)
Potent: Betnovate (betamethasone 0.1%)
Very potent: Dermovate (clobetasol propionate 0.05%)

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89
Q

what is eczema herpeticum?

A

skin infection in pts with eczema caused by HSV, VZV

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90
Q

erythema multiforme drugs causes:

A

drugs: penicillin, sulphonamides, carbamazepine, allopurinol, NSAIDs, oral contraceptive pill, nevirapine

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91
Q

what is koebner phenomenon?

A

causes lesions of molluscum contagiosum to appear at sites of injury
also psoriasis and other conditions

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92
Q

where does pompholyx eczema tend to appear?

A

palms and soles very itchy

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93
Q

uniform area of erythema across the bridge of his nose and extending across his cheeks. Upon this erythema you note there are about a dozen small pustules and papules. Lastly, you note the presence of superficial telangiectasia across the bridge of the nose and a small amount around the labia of the nose.
dx?

A

acne rosacea

cx - blepharitis

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94
Q

tx rosacea?

A
  1. topical metronidazole

2. if resistant or severe PO tetracycline

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95
Q

if rosacea and severe telangietasia - tx?

A

laser tx

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96
Q

tx acne vulgaris?

A

PO retinoids

topical benzoyl peroxide, top clinda, PO doxy, COCP

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97
Q

noticed a patch of pigmented skin on her toe, which has been slowly enlarging over the past five months. On examination, she has pigmentation of the nail bed of her great toe, affecting the adjacent cuticle and proximal nail fold. Which subtype of melanoma would you expect to present in this manner?

A

acral lentiginous melanoma

Hutchinson’s sign

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98
Q

Inpatient treatment for erythroderma must be monitored for complications such as??

A

dehydration, infection, high output heart failure

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99
Q

what is erythroderma?

A

> 95% skin covered in rash of any kind

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100
Q

what is a birthmark that typically resolves and is vascular?

A

salmon patch

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101
Q

A 29-year-old man presents with a lump in his scalp. It is located approximately 4cm superior to the external occipital protuberance. It feels smooth and slightly fluctuant and has a centrally located small epithelial defect. What is the most likely underlying diagnosis?

A

sebaceous cyst

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102
Q

what are most frequently located in the scalp and have an associated central punctum.?

A

sebaceous cysts

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103
Q

A 36-year-old lady presents with localised, well demarcated patches of hair loss and small, broken ‘exclamation mark’ hairs. Which of the following blood tests is most important to do in this case?

A

TFTs

Alopecia areata - AI condition

104
Q

scalp is red with white scales. dx?

A

scalp psoriasis

105
Q

tx scalp psoriasis?

A

high potency topical corticosteroids is 1st line

2. MTX

106
Q

seborrhoeic dermatitis of the scalp. tx?

A

Ketoconazole and over the counter shampoos

107
Q

if long term steroid use, what is advice re breaks?

A

4 week steroid breaks in between courses

108
Q

typically on the lower limbs
initially small red papule
later deep, red, necrotic ulcers with a violaceous border
may be accompanied systemic symptoms e.g. Fever, myalgia dx?

A

pyoderma gangrenosum

tx - po pred

109
Q

causes pyoderma gangrenosum?

A 
idiopathic in 50%
inflammatory bowel disease: ulcerative colitis, Crohn's
rheumatoid arthritis, SLE
myeloproliferative disorders
lymphoma, myeloid leukaemias
monoclonal gammopathy (IgA)
primary biliary cirrhosis
110
Q

A 2-yo with a history of atopic eczema is brought to the local GP surgery. Her eczema is usually well controlled with emollients but her parents are concerned as the facial eczema has got significantly worse overnight. She now has painful clustered blisters on both cheeks, around her mouth on her neck. Her temperature is 37.9ºC. What is the most appropriate management?

A

eczema herpeticum

admit for IV antivirals - emergency

111
Q

cause of eczema herpeticum ?

A

HSV1-2

112
Q

man comes in with larger leg lesions and petechiae over past few days, likely dx?

A

vasculitis

113
Q

formula is used to calculate the volume of IV fluid required for resuscitation over the first 24 hours after the burn?

A

Parkland

114
Q

assessing extent of burns?

A

Lund+Browder chart

115
Q

burns: when to refer?

A

> 2% TBSA kids

>3% TBSA adults

116
Q

what are common complications of seborrhoeic dermatitis?

A

blepharitis and otitis externa

117
Q

Seborrhoeic dermatitis is more common in individuals with which disease?

A

Parkinsons , HIV

118
Q

A 14-year-old rugby player presents complaining of a lesion he has noticed for 2 weeks on his back. On examination of his back, there is a round red ring lesion of approximately 1.5cm in diameter with a central area of clearing. The edge of the rash is elevated and scaly on palpation. Which of the following organisms is the likely cause of this lesion?

A

fungus - tinea corporis

119
Q

which condition presents with hypopigmented, itchy patches? can appear scaly:

A

pityriasis versicolor

120
Q

what type of condition is pityriasis versicolor?

A

fungal infection

malassezia furfur

121
Q

mx pityriasis versicolor?

A

topical ketoconazole

shampoo

122
Q

what can precipitate pompholyx eczema?

A

humidity

123
Q

basal cell papillomas aka?

A

multiple seborrhoeic keratoses

benign epidermal skin lesions on elderly people

124
Q

30-F with BMI 32. recurrence of boils in her axilla. numerous previous eps requiring antibiotics, had an incision and drainage on one occasion. one episode of such boils on her vulva a few years ago. On this occasion, you notice large red lumps in her right axilla. There is some scarring of the skin and you also notice a little hole with pus discharging out of it.
What is the most likely diagnosis?

A

hidradenitis supporativa
chronic, painful, inflammatory skin disorder is characterized by nodules, pustules, sinus tracts, and scars in intertriginous areas

125
Q

complication of hidradenitis suppurativa?

A

sinus tracts and fistulae

126
Q

The use of antivirals for shingles in HI positive patients is to:

A

reduce the risk of post-herpetic neuralgia

127
Q

A 35-year-old female presents with tender, erythematous nodules over her forearms. Blood tests reveal high Calcium. dx?

A

sarcoid, erythema nodosum

128
Q

desquamating rash - skin slippage - think?

A

TENS/SJS

129
Q

systemic itch ddx:

A 
renal pruritis - CKD
cholestatic - bile salt mediated
haematological - polycythaemia vera
endocrine - DM, hyper/othyroid
malignant - HL
psych - promethazine (give)
130
Q

macula vs patch: what does this mean?

A

flat area of altered colour
macula < 1.5cm
patch >1.5cm

131
Q

papule vs nodue: meaning?

A

solid raised palpable lesion
papule <0.5cm
nodule >0.5cm

132
Q

vesicle vs bulla: meaning?

A

raised, clear, fluid-filled lesions
vesicle <0.5cm
bulla >0.5cm

133
Q

pustule vs abscess: meaning?

A

pus-containing lesion
pustule <0.5cm
abscess localised accumulation of pus

134
Q

Wheal definition?

A

Oedematous papule or plaque caused by dermal oedema

135
Q

follicular refers to?

A

face, chest and axillae

136
Q

seborrhoeic refers to?

A

face and scalp

137
Q

eczema: management step-wise:

A 
Identify & avoid triggers
Emollients
Topical Steroids (HEBDO)
Topical calcineurin inhibitors
Bandaging and dressings
138
Q

HEBDO eczema mx:

A 
Hydrocortisone 
Eumovate 
Betnovate 
Dermovate 
Oral
139
Q

what can topical steroids near the eyes cause?

A

glaucoma or cataracts

140
Q

pre-malignant and malignant conditions (skin ca):

A 
Actinic keratosis
Bowen’s disease (squamous cell carcinoma in situ)
Squamous cell carcinoma
Basal cell carcinoma
Malignant melanoma
141
Q

reducing sun exposure is what type of PH prevention?

A

primary prevention

142
Q

4 types of melanoma:

A

superficial spreading (1), nodular, lentigo maligna, acral

143
Q

risk factors for melanoma: (2)

A

sunburn

genetic

144
Q

Rx: melanoma (2):

A

surgery
chemotherapy
(if invasive - wide local excision +SNL biopsy)

145
Q

which skin ca:
Occurs in middle-old age
Usually on head/neck
Raised, pearly or translucent papule with telangiectasia, central ulceration & rolled edge?

A

Basal cell carcinoma

146
Q

Rx: BCC:

A

topical imiquimoid. cryotherapy.
surgery <2cm - wide local excision
>2 - mok’s micographic sx
radiotherapy

147
Q

which skin cancer:
May develop on background of solar keratosis (actinic), Bowen’s disease (leukoplakia) or de novo
Begin as nodules on a firm indurated base, ulcerating as they enlarge
Common on backs of hands and face (especially lower lip & ear)?

A

Squamous cell carcinoma

148
Q

Rx: SCC:

A

surgery

149
Q

3 main groups of fungal infections + 1 eg for each?

A

dermatophytes (tinea/ringworm)
yeast (candidiasis)
moulds (aspergillus)

150
Q

nose, cheeks and forehead

flushing, erythema, telangiectasia → papules and pustules ->

A

acne rosacea

151
Q

acne in pregnancy - mx

A

oral erythromycin

152
Q

A 60-year-old man asks you to have a look at a ‘sore’ on his right ear.
been there 6/12. not painful. dx?

A

actinic keratosis

153
Q

A 17-year-old girl comes to see you at the GP surgery. She complains of excess hair.
She has very fine layer of soft un-pigmented hair that covers her entire body, apart from her palmar and plantar surfaces. cause?

A

malnutrition - lanugo hair

154
Q

65-F -> GP as she has noticed some small spots on her shoulder. She describes small lesions with a number of tiny blood vessels radiating from the middle. You can press down on them, causing them to go white and then refill from the centre. cause?

A

spider navei liver failure

155
Q

Spider naevi can be differentiated from telangiectasia by ?

A

pressing down on them, watching them fill. Spider naevi fill from the centre, telangiectasia from the edge

156
Q

8-M -> GP practice with a red macular rash covering his trunk and back. He has been feeling lethargic for the last two weeks. His mother recalls seeing a larger patch appear on his back initially a week ago, which was then followed by smaller red macules elsewhere on his trunk. His observations are all normal. What is the most likely diagnosis?

A

pityriasis rosea
herald patch
follows viral inf
no tx - 6-12/52

157
Q

33-F itchy rash on both elbows. It has been worsening for the past week. Multiple polygonal, flat-topped papular lesions that each measure 5mm diameter on the flexural surface of her elbows, bilaterally. She has no other rash on the rest of her body. diagnosis?

A

lichen planus

‘violaceous’, mucus membrane involvement

158
Q

dry, fine-scaled, pale patches on the face. It is self-limiting - dx?

A

pityriasis alba

159
Q

Venous ulceration is most characteristically seen above the:

A

medial malleolus

160
Q

32 M sore and itchy skin on his hands and wrists. He has noticed it gets better when he is not in work and wonders if it is something he is coming into contact with at work causing the irritation. Which ix?

A

patch testing

161
Q

An area of rapidly worsening painful eczema is an early sign of?

A

eczema herpeticum

162
Q

59-F -> ED after the sudden appearance of widespread blistering, sore mouth and skin tenderness. 3/7 hx high fevers and malaise. No PMH except amoxicillin for an ear infection two weeks ago. Systemically unwell, 39.2ºC, hr 187, bp 100/54, rr 22, SpO2 98%.
Widespread erythematous bullae and vesicles covering almost half the body surface. Lesions are also present on the oral mucosa and beginning to affect the eyes. Nikolsky’s sign is positive. dx?

A

TEN

163
Q

Nikolsky’s sign:

A

gentle lateral pressure on what appears to be an uninvolved site causes the area of sloughing to extend

164
Q

A 34-F trips over and falls into a bonfire whilst intoxicated. Burns to her arms, torso and face. 25% body surface area. She is otherwise stable. The burns to the torso are superficial, her left forearm has a full thickness burn and the burns to her face are superficial. No airway compromise. She has received 1000ml of intravenous Hartman’s solution, with a further 1000ml prescribed to run over 4 hours. mx?

A

Transfer to regional burn centre once stabilised

165
Q

A 20-M in a warehouse fire. He has sustained 60% burns to his torso and limbs. The limb burns are partial thickness but the torso burns are full thickness. He was intubated by paramedics at the scene and is receiving intravenous fluids. His ventilation pressure requirements are rising. mx?

A

escharotomy

166
Q

An 18-year-old man accidentally pours boiling water onto his left arm. The area is erythematous and has a blister measuring 5cm. The wound is extremely painful.
mx?

A

discharge with review in outpatients

167
Q

Keloid scars are most common on??

A

sternum

enlarged, raised and red scars which are itchy at the site of injury.

168
Q

what is referred to rodent cell ca?

A

BCC

169
Q

BCC: TURP acronym?

A

Telangiectasia - edge
Ulceration - central
Rolled edges
Pearly

170
Q

define psoriasis:

A

chronic autoimmune condition characterised by keratinocyte hyperproliferation

171
Q

nail changes: onicholysis, leukonychia, thickening, pitting, discolouration all seen in?

A

psoriasis

172
Q

Auspitz sign?

A

appearance of small bleeding points after successive layers of scale have been removed from the surface of psoriatic papules or plaques

173
Q

4 key things of acne:

A

increased sebum production
block sebaceous glands, traps keratin
comedone formation -> infection with Propionibacterium acne

174
Q

when to refer in acne vulgaris?

A

after 3 tx tried
psych impact
if pt requests
++ scarring

175
Q

isotretinoin can be used in refractory acne vulgaris when scarring - it has to be used for 6/12 - what should pts be told when going on it?

A

no alcohol, need contraception as super teratogenic, increase suicidal thoughts, increased exposure to sunlight, dry skin

176
Q

eczema patho:(3)

A

chroic atopic condition - defect in epidermal barrier

T-cell upregulation - hypersensitivity reaction - inflammation (IgE - eosinophil). Exacerbating factors

177
Q

melanoma A-E:

A 
Asymmetrical
Borders irregular
Colour changes
Diammeter >6mm
Evolving
178
Q

ix melanoma:

A

2ww excisional biopsy >2mm.
histology dx
(breslow thickness - PROG, ulcer, mitotic index)

179
Q

Isoniazid, an anti-TB medication, may induce?

A

pellagra

180
Q

Four D’s of pellagra (vitamin B3 deficiency):?

A

diarrhoea
dermatitis
dementia
death

181
Q

A pyogenic granuloma may mimic amelanotic melanoma but can be differentiated???

A

based on hx of trauma in PG

large purplish lesion appears at the site which bleeds on contact.

182
Q

65F->GP 3/12 hx of weight loss and feeling generally unwell. She has also noticed the skin under her armpits has become darker and slightly thicker. What is the most common malignancy associated with acanthosis nigricans?

A

GI adenocarcinoma

also seen in t2dm

183
Q

hirsuitism causes:

A 
PCOS - commonest - rx co-cyprindiol
cushing's
congenital adrenal hyperplasia
androgen therapy
obesity
184
Q

ix venous ulcer?

A

ABPI

185
Q

emollient use:

A

2-3x/day initially up to every hour if needed
in direction of hair
leave to soak in rather than rubbing in
after washing

186
Q

2/52 baby ->GP. She has noted a bright red, well-circumscribed and lobulated lesion developing on her right temple. This wasn’t noted at birth but is now 5 mm in diameter. What is the most appropriate management?

A

reassure it will likely resolve after 3/12

strawberry naevus

187
Q

lichen planus is suspected. What is the most appropriate treatment?

A

topical clobetasone butyrate

188
Q

vitiligo tx?

A

sunblock for affected areas of skin
camouflage make-up
topical corticosteroids may reverse the changes if applied early
there may also be a role for topical tacrolimus and phototherapy

189
Q

22M longstanding problem of bilateral excessive axillary sweating. He is otherwise well but the condition is affecting his confidence and limiting his social life. What is the most appropriate management?

A

topical aluminium chloride

hyperhidrosis

190
Q

Dermatophyte nail infections - mx?

A

oral terbinafine

191
Q

A 59-year-old man complains of pruritus and lethargy. On examination he has spoon shaped nails and a smooth tongue. cause of itch?

A

IDA

192
Q

A 57-year-old woman presents with pruritus. She states she has been gaining weight despite eating less and complains of constant nausea. On examination she is pale. cause of itch?

A

CKD

193
Q

A 52-year-old woman presents with pruritus and lethargy. She has recently put on weight and is complaining about dry skin. cause of itch?

A

hypothyroidism

194
Q

75-M ‘sore’ on his lip. This has been present for around four months and has been getting slowly worse. His past medical history includes ischaemic heart disease and chronic obstructive pulmonary disease. He still smokes around 20 cigarettes per day. dx?

A

squamous cell carcinoma

195
Q

pruritic condition associated with last trimester? abdominal striae - periumbilical sparing

A

polymorphic eruption of pregnancy

emollients, top, po steroids

196
Q

often develop in peri-umbilical region, later spreading to the trunk, back, buttocks and arms
usually presents 2nd or 3rd trimester and is rarely seen in the first pregnancy. pruritic blistering lesions. dx?

A

pemphigoid gestationis

po corticosteroids

197
Q

8F have noticed a small growth on the sole of her foot for the last 3/12 that has become painful. Small, firm, hyperkeratotic growth with tiny overlying black dots. dx, tx?

A

plantar wart = verruca

salicylic acid top

198
Q

76M longstanding patch of rough, itchy skin on his scalp which has not changed in size. 1cm area of erythema and some scaling which is rough in texture, with evidence of surrounding sun damage. There is no ulceration or bleeding. dx? tx?

A

actinic keratosis
diclofenac
top fluorouracil cream

199
Q

The most common dermatosis in pregnancy is

A

atopic eruption of pregnancy

-face, neck, chest, extensors

200
Q

Which complication most associated with psoralen + ultraviolet A light (PUVA) therapy?

A

SCC

201
Q

which melanoma Invade aggressively and metastasise early?

A

nodular

202
Q

A 52-year-old man asks you to look at the side of his tongue. The white patches have been present for the past few months and are asymptomatic. He is a smoker who is known to have type 2 diabetes mellitus. dx?

A

oral leukoplakia

asx so not candidiasis

203
Q

lichen planus:

A

purple, pruritic, papular, polygonal rash on flexor surfaces. Wickham’s striae over surface. Oral involvement common
also genitals and palms - white-lace like pattern

204
Q

lichen sclerosus:

A

itchy white spots typically seen on the vulva of elderly women
OR
uncircumcised man, who has developed a tight white ring around the tip of the foreskin and phimosis

tx - 1. topical clobetasol propionate

205
Q

A 41-year-old woman requests a repeat prescription for citalopram. She also mentions she is constantly itchy and bruises easily. On examination she has reddened palms and a distended abdomen. cause of itch?

A

liver disease

206
Q

A 27-year-old woman presents with itch and lethargy. She is having difficulty sleeping due to night sweats and is wondering if she may be ‘going through the change’. A chest x-ray is normal. cause itch>

A

lymphoma

207
Q

A 61-year-old man presents with pruritus. He has had recurrent episodes of painful swelling in the MTP joints and a history of peptic ulcer disease. On examination he has a ‘ruddy’ complexion - cause itch?

A

polycythaemia

208
Q

A 20-year-old woman presents to her GP complaining of a persistent facial rash. On examination, you note erythema of the nose, cheeks and forehead. There are some scattered papules. She has not noticed any particular triggers but does think it is slightly worse in the summer. dx, tx?

A

acne rosacea
top metronidazole

worse after alcohol, sun

209
Q

You notice a flat purple lesion on the babies cheek which has been present since birth. This does not seem to be painful. All other examinations are normal.?

A

port wine stain

210
Q

impetigo - returning to school?

A

no longer contagious which is when all lesions have crusted over or 48h after treatment starts

211
Q

Red or black lump, oozes or bleeds, sun-exposed skin??

A

nodular melanoma

212
Q

drug causes of spider navi?

A

cocp

213
Q

Stress ulcers in burns patients are referred to as?

A

curlings ulcers -> haematemesis

214
Q

A 21-year-old woman with a history of eczema presents with a change in the colour of her skin affecting the hands and feet symmetrically: white patches - dx?

A

vitiligo

AI - addisions associations

215
Q

An 82-year-old Caucasian gentleman presents with a waxy, scar-like plaque over his left eyelid. He reports it to have been slowly increasing in size over the last two years. You diagnose morphoeic basal cell carcinoma (BCC). mx?

A

morphoeic BCC usually is associated more extensive spread than nodular BCC as it is more aggressive and often presents later. poorly defined edges
Mohs microgaphic surgery

216
Q

A 19-year-old man comes for review after burning himself with an iron. On examination he has a 4 by 3 cm area of pale pink skin the left forearm. In the middle of the area there are two small, fluid filled blisters. What is the most accurate description for this type of injury?

A

partial thickness (superficial dermal) burn

217
Q

can cause pulmonary, hepatic, cerebral and spinal AVMs??

A

Hereditary haemorrhagic telangiectasia

also epistaxis

218
Q

A 27-year-old man with a history of depression and coeliac disease presents with an itchy rash on his buttocks: dx?

A

dermatitis herpetiformis

symmetrical vesicular rash - can be arms and legs

219
Q

IV fluids needed in which burns pts?

A

adult: second or third degree burns that cover 15% body surface area or more. In children, IV fluids are recommended when burns cover 10% body surface area.

220
Q

55M new skin lesion to the forehead. On examination there is a 6mm diameter scaly patch which does not appear indurated or ulcerated. He works as a gardener. He has a past medical history of type 1 diabetes and renal transplant, and his medications include insulin, aspirin, simvastatin, and tacrolimus. What is the most appropriate course of action?

A

refer urgent to derm - may be SCC as renal transplaant and immunosuppressed

221
Q

Marjolin’s ulcer?

A

SCC in an area of previous chronic inflammation

222
Q

Children with new-onset purpura (petechial rash) should be mx?

A

refer immediately to paeds to r/o ALL, meningococcal sepsis

223
Q

Management of venous ulceration -?

A

compression bandaging

224
Q

red, scaly patches
often 10-15 mm in size
slow-growing
often occur on sun-exposed areas such as the head (e.g. temples) and neck, lower limbs

A

bowens disease

pre-malignant for SCC

225
Q

A neonate is brought to your surgery because his mother has noticed some skin lesions on his face. On examination there are multiple tiny white papules on the nose. What is the most likely diagnosis?

A

milia - self resolve after a few weeks

half of babies

226
Q

Open and closed comedones, pustules and nodules are all characteristic lesions of?

A

acne vulgaris

227
Q

acanthosis nigrans pathology?

A

insulin resistance → hyperinsulinemia → stimulation of keratinocytes and dermal fibroblast proliferation via interaction with insulin-like growth factor receptor-1 (IGFR1)

228
Q

acanthosis nigrans associations?

A 
insulin-resistant DM
obesity
PCOS
COCP
GI malignancies - gastric and pancreatic ca
229
Q

A 19-year-old female who has just started work as a cleaner presents with a rash on her hands. On examination there is a generalised erythematous rash on the dorsum of both hands. There is no evidence of scaling or vesicles. What is the most likely diagnosis?

A

irritant contact dermatitis

230
Q

43F dermatology evolving lesion on her right lower leg. First noticed 4 months ago, and it has increased in size and changed in colour during this time. 2cm by 1.5 cm asymmetrical pigmented lesion, comprised of several shades of brown. She has Fitzpatrick skin type II and uses sunbeds approximately every 4 months. dx?

A 
superficial spreading melanoma - features of a changing mole 
ABCDE approach (asymmetry, border irregularity, colour variation, diameter >6mm and evolving)
231
Q

melanoma - develops slowly, on chronically sun-exposed skin (the face, neck and arms).?? can be asx

A

lentigo maligna

232
Q

patients with psoriatic arthropathy will have nail changes ?

A

onycholysis

distal interphalangeal joint involvement and dactylitis of the ring finger

233
Q

cx burns?

A

curling’s ulcer
rhabdo
compartment syndrome
hypoalbuminaemia -> oedema

234
Q

sub-epidermal blistering of the skin
itchy, tense blisters typically around flexures
the blisters usually heal without scarring
there is usually no mucosal involvement (i.e. the mouth is spared) - dx, mx?

A

bullous pemphigoid

oral corticosteroids

235
Q

Features - said to look like a volcano or crater
initially a smooth dome-shaped papule
rapidly grows to become a crater centrally-filled with keratin dx>

A

keratocanthroma benign but need to
SCC r/o

should self resolve with scarring

236
Q

which meds cause patchy depigmentation in patients with darker skin?

A

topical corticosteroids

237
Q

infrared radiation and is commonly associated with hot water bottles or open fires
?

A

erythema ab igne

non-blanching

238
Q

large variation in colour from flesh to light-brown to black
have a ‘stuck-on’ appearance
keratotic plugs may be seen on the surface
older man
dx?

A

seborrhoeic keratosis

239
Q

oral antibiotic of choice to treat erythrasma? (flat, slightly scaly, pink or brown rash usually found in the groin or axillae. )

A

erythromycin

240
Q

An 8-year-old boy presented with a painless swelling on the superotemporal aspect of his orbit. It was smooth on examination, produced no visual disturbances. Following excision it was found to be lined by squamous epithelium and hair follicles. dx?

A

dermoid cyst

241
Q

isotretinoin sfx?

A 
dry skin
teratogenic af
low mood*
raised triglycerides
hair thinning
ICH
epistaxis
photosensitivity
242
Q

A 22-year-old man presents to the GP with a mass on his lower back. On examination, there is a 6cm mobile rubbery mass on his lower back just lateral and superior to the sacrum. The mass is not painful and there are no accompanying symptoms. mx?

A

USS lipoma as >5mm

reassurance

243
Q

derm drug -> gynaecomastia?

A

ketoconazole

244
Q

Diabetes, waxy yellow shin lesions - ?

A

necrobiosis lipoidica diabeticorum

245
Q

impetigo mx:

A

topical fusidic acid if hydrogen peroxide not suitable

246
Q

endocrine cause of acne vulgaris?

A

pcos

247
Q

Afro-Caribbean origin = skin type?

A

6

248
Q

A 32-year-old lady attends with a facial rash for several weeks. She has an erythematous rash which looks greasy and has a fine scale over her face affecting her cheeks, nasolabial folds, eye brows, nasal bridge and scalp. What is the most likely diagnosis?

A

seborrhoeic dermatitis

249
Q

Erysipelas is localised skin infection caused by ?

A

strep pyogenes (superficial cellulitis)

250
Q 
erythematous, papular lesions
typically 1-3 mm in size
non-blanching
not found on the mucous membranes
very red?
A

cherry haemangioma

benign - reassure

251
Q

rx for prominent telangiectasia in acne rosacea?

A

laser therapy

252
Q

SLE skin changes:

A

hair loss, photosensitivity, butterfly rash, levido reticularis

253
Q

A 43-year-old man presents to his GP with a persistent skin lesion overlying the right second metacarpophalangeal joint:

A

granuloma annulare

254
Q

Wallace’s Rule of Nine: Each of the following is 9% of the body when calculating surface area % if a burn:

A

Head + neck, each arm, each anterior part of leg, each posterior part of leg, anterior chest, posterior chest, anterior abdomen, posterior abdomen

255
Q

You are a doctor reviewing a 45-year-old man who has presented with large superficial, flaccid vesicles and bullae present on his trunk, alongside mucosal ulceration and oral involvement. On examination, the vesicles and bullae rupture easily on touch and are painful and there is an associated itch. dx, ix?

A

pemphigoid vulgaris

anti-desmosome abs

3b/4 (19 decks)

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