Clinical Approach to Multiple Sclerosis (Hon) Flashcards
Multiple Sclerosis is a disorder of the brain and spinal cord that results from?
Loss of myelin at multiple sites in the CNS
What are the four types of MS?
1) Relapsing remitting
2) Secondary progressive
3) Primary progressive
4) Benign
Which type of MS is the most common?
Relapsing remitting
Most MS patients are diagnosed at what age?
20s and 30s
MS is generally characterized by periods of?
Exacerbation and remission
Which sex does MS affect more?
Which sex generally have a more favorable course?
Around what age does it have a more favorable course?
1) Women
2) Women
3) The earlier the onset (20s)
What studies are sued to make the diagnosis of MS?
1) MRI
2) Lumbar puncture
What is found on MRI with MS?
Multiple ovoid lesions in the periventricular white matter and in the spinal cord
What is found on lumbar puncture for CSF analysis with MS?
Presence of oligoclonal bands &/or increased IgG
What role does medications have for MS?
Maintenance (To decrease the frequency and severity of exacerbations and slow the progression)
In general, MS is diagnosed by?
Multiple lesions over space and time
In general, medications for MS are used in patients with what form?
Ocrevus (ocrelizumab) is the only drug approved to treat?
1) Relapsing forms
2) Primary progressive MS
What medication is used to treat an acute exacerbation in MS?
Corticosteroids
What condition which can be either monofocal or multifocal can mimic MS?
Clinically Isolated Syndrome
A multifocal episode of Clinically Isolated Syndrome (aka Acute Disseminated Encephalomyelitis) is characterized by?
Patient experiencing more than one sign or symptom caused by lesions in in more than one area
