Tobacco, Vaping, Medical Marijuana, and Cannabidiol (Wolff) Flashcards

1
Q

What ingredient found in nearly all cannabis samples has a link with vaping and lung damage?

A

Vitamin E acetate

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2
Q

Nicotine interferes with maturation of?

A

Prefrontal cortex

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3
Q

What are the two main cannabinoids found in marijuana?

A

1) ∆-9-tetrahydrocannabinol (THC)

2) Cannabidiol (CBD)

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4
Q

What is the general MOA of marijuana?

A

Stimulates endocannabinoid (CB1, CB2) receptors

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5
Q

Endocannabinoids are produced on demand in post-synaptic neurons by stimuli that result in elevations of what ion?

This causes activation of?

Synthesized endocannabinoids then diffuse into the synaptic space, travel in a retrograde manner, and bind to what receptor on presynaptic neuron?

A

1) Ca2+
2) DAG-lipase
3) CB1R

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6
Q

What are the two major endocannabinoids?

A

1) anandamide

2) 2-arachidonoylglycerol (2-AG)

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7
Q

The stimulation of presynaptic CB1Rs inhibits?

A

adenylyl cyclase

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8
Q

Anandamide is broken down by what enzyme found principally in postsynaptic cells?

2-AG is degraded by what enzyme found principally in presynaptic cells?

A

1) Fatty acid amide hydrolase (FAAH)

2) MAG-lipase (monoacylglycerol lipase)

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9
Q

CB2 receptors are found primarily on?

A

Immune cells

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10
Q

anandamide and 2-AG have higher affinity for which CB receptor?

A

CB1

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11
Q

What is Dronabinol?

A

Orally administered synthetic ∆-9-THC

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12
Q

Effects of dronabinol such as analgesia, appetite enhancement, muscle relaxation and hormonal actions are mediated by which receptor?

A

CB1

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13
Q

What are the labeled indications for dronabinol?

A

1) Anorexia in AIDS patient

2) Chemotherapy induced N/V

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14
Q

Cannabis can be recommended for chronic pain, especially for?

A

Neuropathic pain

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15
Q

How is CBD generally administered?

A

Orally

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16
Q

CBD accumulates in what tissue?

A

Adipose tissue

17
Q

CBD is extensively metabolized in the liver by?

A

CYP3A4 and CYP2C19

18
Q

How does CBD compare to TCH in terms of psychoactive effects?

A

CBD does not produce the psychoactive effects seen with THC

19
Q

What condition is CBD useful for?

A

Epilepsy

20
Q

What childhood syndromes associated with epilepsy can be treated with CBD?

A

1) Dravet Syndrome

2) Lennox–Gastaut syndrome