14 - Stroke Flashcards

1
Q

What is the definition of a stroke and a TIA?

A

- Stroke: a ‘cerebrovascular accident’, is a ‘serious life threatening condition that occurs when the blood supply to part of the brain is cut off’. The symptoms and signs persist for more than 24 hours and cause an infarction

- TIA: have similar clinical features of a stroke but completely resolve within 24 hours as only temporary blockage

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2
Q

What are the different categories of strokes?

A

- Ischaemic (85%): thromboembolic

- Haemorraghic (10%): subarachnoid, intracerebral

- Other (5%): dissection, venous sinus thrombosis (occlusion of veins causes backpressure and ischaemia due to reduced blood flow), hypoxic brain injury (e.g after MI)

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3
Q

Why shouldn’t you give aspirin when you suspect a stroke?

A

Need to wait till youve done a CT to see if haemorraghic as if so could make things worse

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4
Q

How do we manage strokes in the ED?

A
  • Are they within the window for thrombolysis (<4 hours)?
  • Do a CT head to determine if it is a bleed (if bleed cannot proceed with thrombolysis)
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5
Q

What are some risk factors for a stroke?

A
  • AF, Endocarditis and Valvular disease can all form clots
  • Bifurcation of carotids atherosclerosis
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6
Q

What does a stroke look like on imaging?

A

CT: bleed will show up as bright white with possible mass effect, ischaemia won’t show up early on but as it establishes it becomes hypodense

MRI: rarely done due to takes a long time, ischaemia shows up as high energy signal

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7
Q

Describe the general blood supply to each lobe of the brain?

A

ACA: medial

MCA: lateral

PCA: also supplies midbrain and thalamus

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8
Q

What stroke syndrome would you get if somebody had a stroke involving the anterior cerebral artery?

A

- Contralateral lower limb and genital weakness (lower limb affected worse than upper limb and face)

- Contralateral lower limb and genital sensory deficit

- Urinary incontinence (paracentral lobule that has excitatory and inhibitory neurones on M centre is damaged)

- Split brain or Alien Hand Syndrome (corpus callosum involvement)

- Apraxia (left frontal lobe, cannot complete motor planning)

- Posible dysarthria/aphasia - (unusual sign, may be related to to frontal lobe damage)

- Frontal lobe features (e.g sexual disinhibition, personality changes)

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9
Q

What stroke syndrome would you get if somebody had a stroke involving the proximal middle cerebral artery? (all branches of MCA will be affected)

A

- Contralateral full hemiparesis (face, arm and leg affected as internal capsule affected which carries fibres to face, arm & leg, homonculus supplied by MCA irrelevant)

- Contralateral sensory loss (mainly face and arm due to homunculus but larger areas if internal capsule involved)

  • Contralateral homonymous hemianopia without macular sparing (both optic radiations wiped out)

- Aphasia (Global if left hemisphere affected, cannot understand or articulate words)

- Contralateral neglect (if lesion in right parietal lobe)

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10
Q

Why does a stroke occuring in the MCA have such a high mortality rate?

A
  • Widespread and can cause cerebral oedema
  • Can turn haemorraghic if vessels in infarcted area break down
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11
Q

What is hemispatial neglect?

A
  • Mainly left neglect when right parietal lobe damaged
  • Not acknowledging the left side of space or even your own body exists. Visual fields normal

- Tactile extinction

- Visual extinction

- Anosognosia (won’t acknowledge theyve had a stroke)

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12
Q

What stroke syndrome would you get if somebody had a stroke involving the lenticulostriate arteries?

A

Lacunar strokes: Destruction of small areas of internal capsule and basal ganglia

  • Can distinguish from MCA strokes as no cortical features like neglect and aphasia
  • Pure motor, pure sensory (thalamoperforator arteries supplying thalamus), sensorimotor
  • Contralateral effects as in internal capsule
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13
Q

What stroke syndrome would you get if somebody had a stroke involving the distal middle cerebral artery?

A

Superior division:

  • Lateral frontal lobe
  • Contralateral face and arm weakness due to motor cortex
  • Expressie aphasia as Broca’s area affected if left sided

Inferior division:

  • Lateral parietal and temporal lobe
  • Contralateral sensory loss in face and arm due to sensory cortex
  • Receptive aphasia as Wernicke’s area affected if left sided
  • Contralateral homonymous hemianopia with no macular sparing (both optic radiations)
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14
Q

What stroke syndrome would you get if somebody had a stroke involving the posterior cerebral artery?

A
  • Contralateral homonymous hemianopia (with macular sparing due to collateral supply from MCA)
  • Contralateral sensory loss due to damage to thalamus
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15
Q

What stroke syndrome would you get if somebody had a stroke involving the cerebellum?

A
  • N+V, vertigo, headache, dizziness

- DANISH signs ipsilateral

  • Possible ipsilateral brainstem signs since cerebellar arteries

supply brainstem as they loop round to the cerebellum

  • Possible ipsilateral Horner’s syndrome (sympathetics travel lateral brain stem with cerebellar arteires)

- Possible contralateral sensory signs as predecussation

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16
Q

How do brainstem strokes present?

A
  • Contralateral limb weakness with ipsilateral cranial nerve signs
  • Due to damage of corticospinal tracts above decussation pyramids and damage to cranial nerve nuclei on the same side
17
Q

What stroke syndrome would you get if somebody had an occlusion of the distal basillar artery?

A
  • Can cause sudden death as vessel supplies brainstem and cardiorespiratory centres
  • Visual and oculomotor deficits as branches into midbrain for CNIII nuclei and joins with PCA to supply PVC in occipital

- Behavioural abnormalities

- Somnolence, hallucinations and dream like behaviour as brain stem controls sleep

  • Motor function in tact as cerebral peduncles can get blood from PCA
18
Q

What stroke syndrome would you get if somebody had an occlusion of the proximal basillar artery (at level of pontine branches)?

A

- Locked in syndrome

  • Complete loss of movement of limbs
  • Preserved ocular movement because midbrain is getting supply from PCAs via posterior communicating arteries
  • Preserved consciousness ( because midbrain reticular formation still intact)
19
Q

How do we classify stroke?

A

Bamford (Oxford) Stroke Classification

TACS: unilateral weakness (+/- sensory deficit) of FAL, homonymous hemianopia, higher cerebral dysfunction e.g aphasia

PACS: only 2/3 of the above

POCS: one of the following… CN palsy with contralater motor/sensory deficit, bilateral motor/sensory deficit, conjugate eye movement disorder, cerebellar dysfunction, homonymous hemianopia with macular sparing

LACS: one of the following… pure sensory deficit, pure motor deficit, sensorimotor deficit, ataxic hemiparesis

20
Q

What is the rule of 4s for brainstem strokes?

A
  • 4 CNs in each section
  • 4 motor nuclei in midline and each go into 12
  • 4 midline M’s
  • 4 sides
21
Q

Would you expect any visual field defects in this patient?

A

Yes - MCA occluded so will wipe out optic radiations

22
Q

Which vessel is involved and why is there issues with continence?

A
  • Left ACA distal to anterior communicating artery as would be no issue if proximal to this artery as it is a circle
  • Incontinence as paracentral lobule for continence is affected and genitals are near feet in sensory homunculus
23
Q

Which parts of the brain have been affected and what vessel is involved?

A
  • Occipital, thalamus and temporal
  • Will have visual field defect (left homonymous hemianopia with macular sparing)
  • PCA affected as supplies thalamus causing sensory issues
24
Q

What Oxford classification does this belong to and how may have the patient presented?

A
  • LACS
  • Lenticulostriate arteries involved causing infarction in globus pallidus interna
  • This will cause an loss of inhibition on the thalamus so excess movement contralateral to infarct
25
Q

What vascular territory is this lesion in?

A
  • Superior cerebellar artery
  • Distal to the branches it gives off to the midbrain as no neurological signs
26
Q

What is the diagnosis and which artery is involved?

A
  • Subarachnoid haemorraghe
  • Posterior communicating artery as third nerve palsy so blood is collecting at base of brain and compressing the cranial nerves
27
Q

What is the diagnosis and what risk factors does the patient have for this condition?

A

- Subdural haemorraghe

  • Warfarin
  • Trauma
  • Cerebral atrophy due to dementia and age putting tension on bridging veins
28
Q

What are the DANISH symptoms? (If we get a problem with our cerebelli)

A
  • D - Dysdiadochokinesia
  • A - Ataxia
  • N - Nystagmus
  • I - Intention, tremor
  • S - Slurred, staccato, speech
  • H - Hypotonia / heel-shin test