Cutaneous Drug Eruptions

Question 1

Maculopapular or exanthematous (commonest type of reaction) => Penicillins, Cephalosporins, Anti-epileptics

Acne => Androgens (danazol)

Acneiform => Corticosteroids, EGFR inhibitors

Angio-oedema => ACE-inhibitors

Urticaria => Penicillin, Cephalasporin, Aspirin, NSAIDs, Morphine & Codeine, Iodine, contrast media

Vasculitis => Gold, hydralazine, NSAIDs, Proton-pump inhibitor

Fixed drug eruptions => Phenolphthalein in laxative, Tetracyclines, Paracetamol, Aspirin, Sulfonamide

Pigmentation => Minocycline (black), Amiodarone (slate-grey)

Lupus erythematosus => Minocylicine, anti-TNF biologics, Isoniazid, Interferons

Photo-sensitivity => Thiazide, Quinolones, Tetracyclines, Diuretics, Amiodarone

Answer 1

Pseudoporphyria => Naproxen, Diuretics

Leg ulcers => Hydroxyurea

Anogenital ulcers => Nicorandil

Erythema nodosum => Sulphonamides, Oral contraceptives (OCP)

Erythema multiforme => Barbiturates

Lichen plants-like (lichenoid) => Antimalarials, Thiazides, Statins, Diuretics

Psoriasiform => Methyldopa, Gold, Lithium, Beta-blockers

Stevens-Johnson syndrome => Sulfonamides, Anti-convulsants

Toxic epidermal necrolysis => Sulfonamides, Anti-convulsants, Penicillin, Co-trimoxazole, Carbamazepine, NSAIDs, Allopurinol

Pemphigus => Penicillamine, ACE inhibitors

Erythroderma => Gold, Sulphonylureas, Allopurinol, Carbamazepine