MODULE 2: B5 & B7

Question 1

**Pantothenic acid relationship to CoA?

Answer 1

Pantothenic acid is RAW MATERIAL for CoA

CoA is SYNTHESIZED from Pantothenic acid

Question 2

Pantothenic acid, heme, fatigue

Answer 2

B5 plays a role in HEME SYNTHESIS, so could be used to treat anemia

Question 3

Burning foot sensation associated with was B vitamin deficiency?

Answer 3

B5

Question 4

** Symptoms associated with Biotin deficiency

Answer 4

Rash (around eyes, mouth etc.) 
Alopecia 
Brittle nails 
**Depression, 
**Lethargy, 
**tingling/numbness (paresthesia)
**Ataxia 
** Seizures 
** HALLUCINATIONS

Question 5

** Main functions of Biotin

Answer 5

1. Involved in macronutrient metabolism
2. Cofactors for CARBOXYLASE ENZYMES (involved in F.A. Synthesis, gluconeogenesis, metabolism of branch chain amino acids)
3. Cofactors for Elongase enzymes (involved in enzymes that convert ALA to EPA/DHA)
4. Gene expression

Question 6

3 classes of drugs that deplete biotin

Answer 6

Anticonvulsants
Sulfonamides
Antibiotics

Question 7

** Foods high in Pantothenic Acid (B5)

Answer 7

*virtually all plants and animals

Liver
Beef 
Pork
Chicken 
Cheese 
Egg 
Mushrooms
Broccoli 
Avocado etc.

Question 8

** Principal function B5/Pantothenic Acid

Answer 8

Synthesis of CoA

Question 9

** Pantothenic acid and metabolism of carbs, lipids, and protein

Answer 9

Metabolism of all depends on CoA (made from B5)

Acetyl-CoA is a common intermediate of all three energy-producing nutrients

Intersects catabolic and anabolic pathways

Question 10

** Symptoms of B5 deficiency

Answer 10

Burning foot syndrome!

Muscle weakness
Fatigue
Arm and leg cramping
Irritability

Question 11

** B6 function with heme synthesis

Answer 11

B6 (as PLP) acts as coenzyme that is necessary in first step of heme synthesis

Question 12

** Adverse reactions to B6 toxicity

Answer 12

Causes SENSORY AND PERIPHERAL NEUROPATHY

• Ataxia
• Impaired motor control
• DEGENERATION of neurons/sensory fibers
• LOSS OF MYELINATION