multisystem autoimmune disease Flashcards
ex connective tissue diseases
SLE scleroderma sjogren's syndrome autoimmune myositis mixed connective tissue disease
ex connective tissue diseases
SLE scleroderma sjogren's syndrome autoimmune myositis mixed connective tissue disease
ex systemic vasculitis
giant cell arteriris
granulomatosis polyangitis
microscopic polyangitis
SLE
more often woman, onset 15-50
ANA
SLE any 4 of
malar rash discoid rash oral ulcers photosensitivity serositis arthritis ANA unexplained seizures, psychosis proteinuria low WCC, platelets, lymphocytes haemolytic anaemia
SLE rx options
hydroxychloroquine
NSAIDs
corticosteroids
scleroderma
functional + structural abnormalities small blood vessels
fibrosis of skin, internal organs
production of autoantibodies
risk factors scleroderma
FHx
ANA
features of scleroderma
Reynaud's arthralgia, myalgia hand + feet swelling digital pits/ulcers loss hand function dyspnoea skin thickening telangiectasia
complications of sceloderma
limited: pulmonary HTN
diffuse: pulmonary fibrosis, renal crisis, small bowel bacterial overgrowth
Sjogren’s syndrome features
dry eyes dry mouth parotid gland enlargement fatigue myalgia arthralgia vasculitis
Sjogren’s syndrome complications
neuropathy lymphoma purpura interstitial lung disease renal tubular acidosis
giant cell arteritis
granuolomatous vasculitis of large and medium sized arteries
giant cell arteritis: 3+ of
new headache age onset 50+ ESR 50+ abnormal temporal a. biopsy temporal artery tenderness or reduced pulsation
giant cell arteritis features
headache vision loss polymyalgia rheumatica Sx fatigue extremity claudication
