Lecture 5 Haemostasis Bleeding and Thrombosis

Question 1

When you get a clot describe how a primary clot and fibrin clot is formed

Answer 1

Binds to collagen
Binds to vWF
Platelets bind to each other = primary clot
Platelet binds to fibrinogen = fibrin clot

Question 2

What is definitive haemostasis

Answer 2

Formation of fibrin clot

Question 3

Name the clotting agents

Answer 3

Factor XII
Factor XI
Factor IX
Factor VIII
Factor X
Prothrombin
Fibrinogen

Question 4

Haemophilia B is caused by a deficiency in what clotting agent

Answer 4

Factor IX (9)
9B

Question 5

Haemophilia A is caused by a deficiency in what clotting factor

Answer 5

Factor VIII (8)
A8

Question 6

Prothrombin is converted to Thrombin by

Answer 6

Xa

Question 7

Thrombin cleaves fibrinogen to___

Answer 7

Fibrin = fibrin clot

Question 8

What is the function of TFPI

Answer 8

Binds and inhibits VIIa and X

Thrombin is not made and clots are not made

Question 9

What is the function of Activated protein C

Answer 9

Binds to cofactor protein S which switches off VIIIa and Va

Question 10

What is the function if anti-thrombin

Answer 10

Protease inhibitor

Inactivates XIa, thrombinm IXa, Xa, VIIIa and inactivates it

Question 11

What proteins are involved in fibrinolysis

Answer 11

Plasminogen is converted to plasmin

Plasmin attacks clot and produces fibrin degradation products

Question 12

What protein prevents degradation of fibrin clot

Answer 12

PA1

Question 13

Name 3 ADP inhibitors

Answer 13

Clopidogrel
Prasugrel
Ticagrelor

Question 14

Name a COX inhibitor

Answer 14

Aspirin

Question 15

What is the mechanism of warfarin

Answer 15

Vitamin K antagonist